Senior Scientist

London
1 month ago
Applications closed

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Location: London

Hours: full time permanent - 40 hours per week

Role overview

Lead and deliver client-facing biomarker projects within a Core Labs programme, with a focus on developing and validating targeted assays (proteomics, lipidomics, metabolomics) and ensuring high-quality delivery for clinical trial studies. This role combines hands-on scientific leadership in mass spectrometry, operational project delivery, quality/compliance awareness, and direct collaboration with external study teams.

Key responsibilities

  • Lead client projects within the Core Labs programme and drive end-to-end scientific delivery.

  • Validate targeted proteomic, lipidomic, and metabolomic assays to appropriate clinical standards (e.g., GCLP, CLIA).

  • Design and execute complex experiments; analyse, interpret, and report data under limited supervision.

  • Deliver biomarker study outputs for clinical trials in line with scope of work and sponsor timelines.

  • Manage day-to-day operational activities across clinical biomarker projects.

  • Support preparation and adherence to trial documentation (e.g., project protocols, data transmittal forms).

  • Ensure project documentation is complete, current, and stored appropriately.

  • Own and maintain key project processes and plans (e.g., project management, communication, escalation, risk plans) and keep records within relevant CTMS.

  • Identify scope changes and work with internal teams to update work orders as requirements evolve.

  • Prepare metrics and reporting for clients and senior stakeholders.

  • Support pre-sales activity alongside commercial leadership by contributing to methodologies, procedures, and analytical pipelines.

  • Create and contribute to SOPs for both the overall service and individual projects.

  • Engage directly with customers and liaise with external study teams to ensure smooth delivery, including attending progress meetings when required.

  • Travel (domestic and international) may be required.

  • Undertake other duties aligned to the role, as requested by the line manager.

    Skills and experience

  • Degree in a relevant biomedical discipline (essential); PhD in biochemistry or related subject (desirable).

  • 3+ years’ experience in mass spectrometry operation and method development (essential).

  • Experience using Waters triple quadrupole instrumentation (essential).

  • Demonstrated experience in mass spectrometry data analysis and assay development (essential).

  • Research or clinical lab experience handling human samples (essential).

  • Clinical laboratory experience and/or experience developing analytical assays (desirable).

  • Quality/compliance exposure within clinical trials settings and/or clinical mass spectrometry (desirable).

  • Excellent written and spoken English (essential).

  • Strong IT skills (Word, Excel, Access, PowerPoint) (essential).

  • Proven ability to troubleshoot equipment issues and maintain accurate records (essential).

    Personal attributes

  • Strong commitment to translational research, with sound judgement and the confidence to escalate when needed (essential).

  • Proactive, adaptable, and willing to learn new techniques (essential).

  • Collaborative team player who can also work independently and deliver effectively (essential)

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