Senior Analytical Scientist – Mass Spectrometry - Antibody Drug Conjugates

Location:London, UK (Hybrid)

Are you ready to revolutionize oncology treatments? Join an innovative biotech company at the forefront of developing proprietary Antibody-Drug Conjugates (ADCs) that are redefining cancer care. With a strong pipeline of clinical and preclinical programs, this company is blending expertise in antibody engineering, bioconjugation, and analytical sciences to deliver life-changing therapies.

Their state-of-the-art labs are the epicenter of groundbreaking R&D, and they’re seeking a talentedSenior Analytical Scientistto drive the development of next-generation ADCs, using cutting-edge analytical techniques and mass spectrometry.

Your Role:

• Lead the development of robust antibody characterization workflows, including stress testing, sequence liability analysis, and PTM/glycan profiling.
• Collaborate with Bioconjugation and Downstream Manufacturing teams to optimize analytical protocols, including drug-to-antibody ratio (DAR) determinations.
• Partner with Antibody Engineering to innovate and characterize novel antibody and ADC formats.
• Keep meticulous records of experiments and foster seamless communication across interdisciplinary teams.
• Play a pivotal role in a cross-functional project team, advancing preclinical ADC assets through the early stages of drug discovery.

Your Expertise:

• Qualifications:BSc/MSc in Life Sciences or Chemistry with a strong foundation in Biochemistry.
• Analytical Skills:Mastery of mass spectrometry techniques (e.g., peptide mapping, DAR determination), proficiency with tools like MassHunter and Agilent systems.
• Technical Proficiency:Expertise in LC-MS, HIC-HPLC, SEC, IEX, and RP-HPLC; experience with Chromeleon and Vanquish UHPLC systems is a bonus.
• Track Record:Demonstrated ability to develop and troubleshoot analytical methods for protein and conjugate characterization.
• Collaboration:Excellent interpersonal and communication skills, thriving in multidisciplinary environments.
• Industry Savvy:Experience in biotech or industry settings.

Bonus Points For:

• HPLC expertise in protein quantitation, charge variant analysis, and glycan profiling.
• Small molecule mass spectrometry, including payload cleavage studies.
• Hands-on experience with AKTA purification systems and Unicorn software.
• Familiarity with biomolecule tracking software like Genedata Biologics.

What’s In It for You?

This role comes with a competitive benefits package, including:

• Annual travel allowance and performance-based bonus.
• 30 days of holiday plus bank holidays, with an additional Christmas shutdown.
• Matched pension contributions, private health insurance, share options, and social incentives.

Why Join?

Be part of a dynamic, forward-thinking team that values scientific innovation and collaboration. This is your chance to work on transformative oncology therapies, expand your expertise, and contribute to a mission that truly makes a difference.

Take the next step in your career—apply now and help shape the future of cancer treatment!