Proteomics Scientist

Job Description

Main Purpose of the Job

The Proteomics Scientist will work within the Proteomics Platform at JIC to provide proteomics support to a diverse array of researchers. The role will span multiple aspects of complex proteomics experiments, including advising on experimental design, instrument maintenance and operation, method optimisation, data analysis pipelines, interactions with users/clients, training, sample preparation, data processing, presentation of data, and contributions to associated manuscripts.

Key Relationships

Internal:Line manager, proteomics platform manager and, as necessary, other researchers, research support staff and students across the Institute.

External:TSL proteomics team associated with equipment sharing; other clients and collaborators from external institutions; engineers and support specialists associated with proteomics equipment

Main Activities & Responsibilities

Operate and maintain several advanced mass spectrometers including the requisite software and nano-scale liquid chromatography systemsPrepare samples for proteomics analysis including protein quantification, enzymatic digestion, isobaric labelling, sample clean upRun samples on a nanoLCMS system with an Orbitrap Eclipse mass spec for proteomics analysisProcess mass spec raw data for peptide/protein identification and quantificationSupport proteomics projects through employing efficient and accurate data evaluation techniques, placing levels of statistical confidence on data output, and clearly reporting resultsInteract with faculty and staff and present technical data through presentations and report writingTrain others on procedures, operations and new technology, or methodsEnsure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirementsContribute methods, data and analysis to associated research publicationsAs agreed with line manager, any other duties commensurate with the nature of the role

Person Profile

Education & Qualifications

RequirementPhD or other research role with significant proteomics experienceMSc/BSc or equivalent in biological sciences

Specialist Knowledge & Skills

RequirementExpertise in running and analysing proteomics experimentsProficiency in quantative proteomics methods, such as isobaric labelling mProficiency with common mass spectrometry proteomics data analysis softwareKnowledge in protein separation and enrichment sciences.Knowledge and interest in biological protein structure, function and interaction.Proficiency in data dependent and data independent acquisition modes

Relevant Experience

RequirementExperience of oral research presentations and written presentationsExperience of supervising, training and mentoring visitors and studentsPreparing data / information for grant proposalsExperience in working with different types of mass spectrometers including Orbitrap and MALDI-TOF Experience with mass spectrometry imaging

Interpersonal & Communication Skills

RequirementExcellent communication skills, both written and oral, including the ability to present complex information with clarity Good interpersonal skills, with the ability to work as part of a teamDemonstrated ability to work independently, using initiative and applying problem solving skillsExcellent time management and organisational skillsAbility to collaborate with internal and external stakeholdersAbility to follow instructions/Standard Operating ProceduresPromotes and strives for continuous improvement

Additional Requirements

RequirementPromotes equality and values diversityWillingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to workAble to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Ability to maintain confidentiality and security of information where appropriate Willingness to work outside standard working hours when required Ability to undertake occasional travel (national and international) related to collaborations and/or seminars Attention to detail