Principal Scientist - Non-clinical PKPD

Hays
Slough
6 months ago
Applications closed

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Your new company
You will be joining a leading global biopharmaceutical company based in Slough who are looking for a Principal Scientist to join their Non-Clinical PK/PD team within Early Clinical Development & Translational Sciences. This contract role (12 months) focusses on the design and execution of non-clinical PK/PD and GLP toxicokinetic (TK) studies, playing a key role in shaping pharmacokinetic and pharmacology strategies.The successful candidate will contribute to DMPK and PK/PD activities across the drug development continuum, from target identification through to life cycle management, supporting the advancement of innovative therapeutic programmes.


Your new role

  • Lead the design and execution of non-clinical PK/PD and GLP toxicokinetic studies, shaping and driving the overall non-clinical pharmacokinetic/pharmacodynamic (PK/PD) strategy.
  • Contribute to the development of study protocols, including regulatory and exploratory designs, to support the progression of innovative therapeutic candidates.
  • Collaborate cross-functionally with internal and external teams
    to gather requirements, align objectives, and ensure timely delivery of project milestones.
  • Advance drug development efforts by applying deep expertise in drug pharmacology and PK/PD to inform decision-making and optimise candidate selection.
  • Serve as a key liaison between stakeholders, effectively representing departmental interests and ensuring alignment with broader organisational goals.



What you'll need to succeed

  • A PhD or MSc (or equivalent experience) in quantitative pharmacology, pharmacokinetics /pharmacodynamics, DMPK, biology or a related discipline, with strong hands-on experience in PK/PD within a pharmaceutical, biotech, CRO or consultancy environment.
  • Proven expertise in non-clinical PK/PD study design, data analysis, and regulatory reporting, with a strong understanding of pharmacology and disease-related drug mechanisms.
  • Demonstrated hands-on experience in generating and interpreting high-quality preclinical PK/PD data to support drug development.
  • Proficiency in Phoenix WinNonlin for PK/PD analysis is essential; experience with additional modelling and simulation tools such as Berkeley Madonna and/or R is highly desirable.
  • A track record of scientific publications and contributions relevant to PK/PD is considered an asset.



What you'll get in return
The chance to make a significant impact on the company's portfolio and work within a highly experienced team.


What you need to do now
If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.
If this job isn't quite right for you but you are looking for a new position, please contact us for a confidential discussion on your career.

Keywords: Principal, Scientist, Nonclinical, PKPD, Pharmacokinetics, Pharmacodynamics, PK, PD, Toxicokinetics, GLP, Compliance, Phoenix, WinNonlin, Berkeley, Madonna, R, Programming, Quantitative, Pharmacology, DMPK, Drug, Development, Preclinical, Translational, biotech, pharma, Clinical, Bioanalysis, Immunogenicity, Safety, Regulatory

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