Principal Bioinformatician - Drug Development

Your new company

Join a global biopharmaceutical organisation dedicated to transforming patient outcomes across multiple disease areas. You'll be part of a science‑driven environment that values innovation, collaboration, and meaningful impact and work with highly experienced colleagues.

Your new role

This is a permanent role within a well-established team where you will be reporting into senior bioinformatics leadership.The company has a collaborative and innovative atmosphere, where you will be supporting multiple projects within translational and clinical development across several therapy areas.

The role is hybrid, with c.3 days per week from home, though this can be negotiable for the right candidate.

As a Principal Bioinformatician within drug development, you will play a key role in generating biological insights from clinical stage omics data to support decision making across the therapeutic portfolio.

Major responsibilities will include:

Processing, analysing, and interpreting multi‑omic (RNAseq, NGS, proteomic, etc) datasets from clinical studies

Deriving mechanistic, biological, and treatment related insights from patient‑level data

Developing and optimising analysis methods, pipelines, and computational workflows

Ensuring reproducibility and best practice documentation for code and analyses

Drafting high quality reports and contributing to scientific publications

Applying SOTA (state‑of‑the‑art) tools for functional interpretation (e.g., pathway enrichment)

Integrating omics outputs with clinical variables to enhance understanding of drug effects

Operating autonomously while collaborating with cross‑functional scientific teams

What you'll need to succeed

A strong candidate will bring senior‑level experience in clinical bioinformatics along with:

An MSc / PhD (or equivalent experience) in bioinformatics, computational biology, statistical genetics, biology, or a related subject

Significant expertise in analysing bulk and single‑cell RNA‑seq from complex or clinical studies, with a significant preference for candidates who have done this in an industry (pharma, biotech, CRO) setting

Experience with multi‑omics integration, functional interpretation, and pathway analytics

Strong computational skills, including HPC, cloud platforms, and containerisation tools

Proficiency in R and other commonly used bioinformatics programming languages

Solid grounding in statistics, data mining, and biological data visualisation

Ability to clearly communicate findings to both expert and non‑expert audiences

What you'll get in return

As well as an excellent opportunity to progress and develop your career within an innovative and collaborative work environment you'll be making a significant impact on the next generation of medicines and the patients they treat.

You'll also have plenty of flexible working options and a generous salary and benefits package.

What you need to do now

If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.

If this job isn't quite right for you, but you are looking for a new position, please contact us for a confidential discussion on your career.

Keywords: bioinformatics, bioinformatician, drug, discovery, pharmaceutical, biotech, clinical, principal, omics, RNAseq, single-cell, computational, analysis, pipeline, genetic, genomics, proteomics, epigenetic, spatial, data, integration, pathways, enrichment, causal, mechanisms, disease, biology, statistics, visualisation, programming, R, immunology, neuro, CNS, oncology, cancer, inflammation, respiratory