Principal Scientist

We are partnered with an innovative early-stage biotech company based in Oxfordshire who are seeking a Principal Scientist to join their growing Biology team. This is a great opportunity for a highly motivated, experienced, hands on scientist who is keen to play a key scientific role in shaping the future of a new therapeutic modality from its foundational stages.

Your responsibilities will include:

• Develop and optimise cellular and molecular assays to evaluate therapeutic candidates
• Execute experiments involving qPCR, western blotting (including capillary systems), ELISA, luciferase assays, and nucleic acid transfection
• Lead in vitro screening efforts to assess compound efficacy and mechanism of action
• Collaborate with CROs, academic partners, and internal teams to meet project milestones
• Contribute to target and indication selection strategies for new therapeutic programs
• Maintain clear and accurate records using electronic lab notebooks and present findings to stakeholders
• Ensure compliance with good laboratory practices and health & safety protocols

To be considered for this role you will need:

Essential

• PhD in molecular biology, cell biology, biochemistry, or related discipline
• At least 7 years of relevant experience in industry or academia
• Strong practical expertise in protein quantification techniques (e.g., western blot, ELISA)
• Proficiency in mammalian cell culture and transfection methods
• Skilled molecular biology techniques including qPCR, luciferase reporter assays, and nucleic acid extraction
• Experience working with CROs, particularly in the design and oversight of in vivo studies
• Excellent collaboration, communication, and organisational skills
• Willingness to work full-time on site in Oxford

Desirable

• Familiarity with indication finding activities
• Previous line management or mentorship experience