Senior Scientist - TCR Cell Therapy (Oncology)

Senior Scientist TCR Cell Therapy (Oncology)
Location: Oxfordshire
Department: R&D Oncology / Cell Therapy
Salary: £50,000£60,000 pa plus Benefits
About Us
Executive Recruitment have again been retained by this innovative biotech based in Oxfordshire specialising in engineered T-cell receptor (TCR-T) therapies targeting solid tumours. Their mission is to deliver next-generation immunotherapies with enhanced specificity and clinical impact. To that end we are looking to speak with Senior Scientists within this niche area of expertise. More about the role below.
Key Responsibilities
Lead design and execution of in?vitro and ex?vivo functional assays to evaluate engineered TCR-T constructs (cytotoxicity, proliferation, cytokine release).
Develop and optimise immunophenotyping methods using multi-colour flow cytometry, ELISA/ELISPOT, T-cell isolation, expansion, and killing assays.
Conduct preclinical study designs, including lentiviral/retroviral transduction of T cells, gene editing (e.g., CRISPR/Cas9), and cell therapy process development.
Interpret experimental data, drive go/no-go decision-making, and present findings internally and externally.
Mentor junior scientists, maintain lab quality standards, and collaborate with cross-functional teams (bioinformatics, translational research, in?vivo).
Stay updated on TCR-T and CAR-T advances, incorporating new technologies and publications into R&D strategy.
Technical Skills
Fluency in multi-parameter flow cytometry (including immunophenotyping and high-content analysis)
Robust experience with functional T-cell assays (cytotoxicity, proliferation, cytokine release, ELISPOT)
Molecular biology expertise: gene editing (CRISPR), stable cell line generation, gene expression analysis
Familiarity with pre-clinical in?vivo or translational assay systems (desirable)
Professional Skills
Strong analytical capabilities with data interpretation and statistical presentation
Excellent written/oral communication. Comfortable presenting to multidisciplinary audiences and publishing scientific outputs
Proven ability to mentor and manage junior staff
Collaborative mindset within cross-functional, fast-paced R&D teams
Education & Experience
PhD in Immunology, Cell Biology, Molecular Biology, or related field (MSc industry experience may be considered)
3 years post-doctoral or industrial experience working with TCR-T or CAR-T cell therapies
Experience with viral vectorbased transduction, T-cell isolation/expansion, gene editing, and primary human cell assays
If you have the skills, experience and desire to part of this industry leading company then please do not hesitate to apply.

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