Senior Scientist I - Characterisation | CMC - Oxford

Senior Scientist I - Characterisation | CMC -OxfordImmunocore (NASDAQ: IMCR) is a pioneering, commercial-stage Tcell receptor biotechnology company whose purpose is to develop andcommercialize a new generation of transformative medicines whichaddress unmet patient needs in oncology, infectious diseases andautoimmune disease. Our leaders in R&D are internationallyrecognised as some of the biotech industry/'s most successful drugdevelopers. We are creating not just an environment where greatminds can interact but an innovation powerhouse answering the bigquestions. Focused on delivering first-in-class biologicaltherapies to patients, we have developed a highly innovativesoluble TCR platform. Our ImmTAX molecules underpin a newgeneration of precision engineered drugs that harness the immunesystem to treat a broad spectrum of diseases with high unmetmedical need, including oncology, infectious diseases andautoimmune diseases. At Immunocore, we recognize that our employeesare our greatest asset. We value the unique contributions eachperson brings to our team. By embracing Science, Trust, Respect,Integrity, Diversity, and Entrepreneurship (STRIDE), we create anenvironment where collaboration thrives, ideas flourish, andtransformative changes happen. STRIDE represents more than justletters; it embodies our shared identity and drives our mission. Weare dedicated to developing breakthrough therapies that transformpatients/' lives, advancing medicine, and supporting one another inthese pursuits. Immunocore is proud to be an equal opportunityemployer. As such, we are committed to fostering an inclusiveworkplace where everyone feels valued, respected, and empowered. Weencourage applications from individuals of all backgrounds,regardless of race, color, religion, sex, sexual orientation,gender identity or expression, pregnancy, age, national origin,disability status, or any other characteristic protected by law.Tocharacterise the companies biotherapeutic recombinant T-cellreceptor based and related molecules using a wide variety ofprotein characterisation and mass spectrometry methods. Tocontribute to the development of characterisation methods for thecompany/'s biopharmaceutical products, including peptide mapping(LC-MS/MS) and intact mass spectrometry analysis. KEYRESPONSIBILITIES* Supporting drug substance and drug productimpurity characterisation and identification* Performing proteinsequence and post translational modification identification,including glycosylation analysis. * Supporting drug substance anddrug product process development by performing characterisation ofprocess intermediates * Contribute to the Development ofcharacterisation methods of ImmTAX and other products, includingpeptide mapping (LC-MS/MS) and intact mass analysis * Designing andcarrying out biochemical characterisation, chemical stability andcomparability studies of biologics/drug products. * Contribute towriting study protocols and reports.* Independently testing and,increasingly, leading lines of investigation. Proposing newexperiments based on emerging data and other related information.Providing support on technical aspects to others. * Priorities:establishing priorities for own work and team-based projects;making decisions on prioritisation based on the overall goals ofthe team, department and project, using direct evidence andpersonal experience as guidance. * Technical Knowledge: sharingknowledge with the wider team and, across departments representingthe department. May also act as a mentor to other colleagues,sharing scientific knowledge. Providing analysis of new techniquesand theories from outside the Company to advance the way thecompany works; sharing these with leaders across the department.Laboratory records: ensuring that all records and information areup to date, on time and recorded to the correct standard.Supporting and encouraging others to achieve this.Laboratoryequipment: providing technical guidance to others within the teamon how to use equipment most effectively.* Reporting: communicatingand presenting research findings at meetings with colleagues,senior management and partners.* Adhere to safe working practicesin laboratories according to Immunocore EHS policies.PERSONSPECIFICATIONExperience & knowledgeEssential* Experience indevelopment of HPLC based peptide mapping methods and massspectrometric characterisation of recombinant proteins orantibodies. * Experience of glycosylation analysis of recombinantproteins or antibodies.* Independently coordinated extensivetesting of protein biomolecules.* Experienced in thecharacterisation of proteins expressed in both microbial andmammalian systems.* Understanding of expected post-translationalmodifications in biological systems.* Worked in a bench-basedbiopharmaceutical laboratory environment. * Established as anexpert amongst peers in one or more of the following areas: oelectrophoretic o chromatographic o mass spectrometry* Experiencedin assay development * Familiar with biopharmaceutical stabilitystudy principles and interpretation thereof* Worked and contributedactively in a diverse team environment* Proposed and driven changesin working practices that have improved efficiency, supported teamsthrough adoption and change* Presented detailed scientific findingsand papers to internal and external audiencesDesirable * Experienceof glycosylation analysis of recombinant proteins or antibodiesExperience with late stage/commercial biopharmaceutical assaydevelopment and characterisation * Familiar with the principles ofGood Manufacturing Practise (GMP)Presented at externalconferences* Led a small project team, formally or informally,through a change in practice including project managementUnderstanding of analytical requirements to support materials foruse in clinical trialsEducation & qualificationsEssential:BSc. Or MSc. in biochemistry, biotechnology or related discipline*Desirable: PhD in related discipline