Senior Scientist

MSAT Senior Scientist I – Downstream Process Development (DSP)

Location: London

Full-time | Permanent

Are you ready to play a key role in advancing novel AAV gene therapies from development to commercialisation?

We’re seeking aDownstream Process Development Scientistto join a collaborative and dynamicManufacturing Sciences and Technology (MSAT)team. You’ll help shape the future of gene therapy by driving innovation in downstream and drug product unit operations—from early-stage development through to GMP tech transfer.

About the Role

You will:

• Lead or support the development ofdownstream processes(chromatography, filtration, TFF, formulation, fill/finish) for novel AAV products.
• Transfer processes from lab-scale to GMP facilities.
• Execute and document development studies and protocols.
• Contribute toclinical and commercialmanufacturing campaigns.
• Mentor junior team members and contribute to the knowledge base within MSAT.
• Drive technical excellence and innovation, leveraging high-throughput tools, statistical and mechanistic modelling, and DoE principles.
• Collaborate cross-functionally with manufacturing, quality, and analytical teams.

Background and Qualifications

• PhD/EngD with 2+ years’ industry experience
• OR
• MSc/BSc with 4+ years' experience in downstream process development.

Key Skills and Experience

• Experience withAAV purification,TFF, andchromatography(ion exchange, affinity, etc.).
• Understanding ofGMP,QbD, and scale-up principles.
• Familiarity withstatistical tools(DoE, ANOVA, t-tests, multivariate analysis).
• Analytical assay experience (qPCR, ELISA, HPLC, UV-spectrometry).
• Experience drafting SOPs, work instructions, and supporting regulatory documentation.
• Knowledge ofmechanistic modelling,programming, orautomated data handlingis a bonus.

What We’re Looking For:

• A sharp analytical mindset and strong problem-solving skills.
• Excellent communication—written and verbal.
• Collaborative spirit with the initiative to take ownership of work.
• A passion for improving bioprocesses through innovation and scientific rigour.

If you are interested, please apply here or feel free to send your cv to my email: