Senior Research Scientist I

Job Title : Senior Laboratory Research Scientist – Structural Biochemist (SLRS)  Details of the role : 2 yr fixed term, full-time. Monday – Friday.  The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.   The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.   The Enchev Lab is offering a unique opportunity to get involved in developing and applying methods for directly observing biochemical processes at atomic spatial and millisecond time resolution. By iterating this procedure at increasing incubation times and using machine learning-based approaches to map conformational landscapes, we generate time-lapse "movies" of biochemical binding and enzymatic reactions.  This role will support academic and industry collaborations and early-stage proof-of-concept trEM studies. Projects may vary in scope and duration. A representative example includes cloning, recombinant production, and biochemical purification of Cullin-RING ligases and their substrates, followed by biochemical characterization, time-resolved cryo-EM sample preparation, data collection, and analysis. Independently perform single-particle cryo-EM screening and data collection. Perform model building into high-resolution cryo-EM maps.   PhD in biochemistry (or related fields) or equivalent experience Practical experience with protein expression, purification and in vitro protein biochemistry Theoretical and practical expertise in cryo-electron microscopy, single particle analysis and model building Track record of writing papers as evidenced by preprints and/or publications in peer-reviewed journals Evidence of data presentation at scientific meetings  We make space for creative, dynamic and imaginative ideas and approaches. We show respect for one another, work cooperatively and support the wider community.   At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. would like to apply by phone or post) please email: nicola.Visas : Applicants for this role will be eligible for sponsorship to work in the UK   Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays.   Pension Schem e: Defined contribution pension with employer contributions of up to 16%.   Occupational health services and mental health support programs.  ~ Eye care vouchers and discounted healthcare plans.   Work-Life Balance :   Childcare support allowance.   Annual leave purchase options.   Crick Networks offering diverse groups’ support, community and inclusive social events.  Discounted gym memberships, bike-to-work scheme, and shopping discounts.   Comprehensive training, mentoring, and a pay structure based on skills and experience.