15h Left! BRF GeMS Research Scientist

Job Description BRF GEMS Research Scientist /n/nReports to: GeMs Senior Manager Molecular & Cell. /n/n This isa full-time, permanent position on Crick terms and conditions /n/nWorking pattern: Monday – Friday. /n/n About us… /n/n The FrancisCrick Institute is Europe’s largest biomedical research instituteunder one roof. Our world-class scientists and staff collaborate onvital research to help prevent, diagnose and treat illnesses suchas cancer, heart disease, infectious diseases and neurodegenerativeconditions. /n/n The Crick is a place for collaboration, innovationand exploration across many disciplines. A space where thebrightest minds can pursue big and bold ideas and discover answersto crucial scientific questions. We support them in a dynamicenvironment which fosters excellence with state-of-the-artinfrastructure, cutting-edge facilities, and a creative and curiousculture. We’ve removed traditional boundaries of departments,divisions and disciplines and instead have an open approach thatsupports every researcher. This gives us the freedom to take risksand carry out high-quality, pioneering research. Creating a spacefor discovery without boundaries helps us to turn our science intobenefits for human health and the economy. /n/n About the role…/n/n The Genetic Modification Services (GeMS) provide a breadth ofspecialist skills and resources for the design, creation,production, storage and use of genetically altered animals,germplasms and cell lines together with ancillary techniques. /n/nThe post-holder will join the genetic modification team and assistin the design and generation of molecular reagents used in both invivo and in vitro genetic engineering experiments for thegeneration of animal and disease models and the subsequent geneticvalidation of the resulting mutant strains. /n/n If you have adegree in a biological subject and have experience in a molecularbiology, mammalian cell culture and CRISPR-Cas9, this could be aperfect opportunity for you to join the team. /n/n You willparticipate in the creation of new animal models, taking a leadrole towards the development of a subset of projects. As such, youwill be expected to develop a detailed understanding of geneticmodification and mouse genetics and will be expected to followbreeding progress ensuring that the 3R’s principles for in vivoresearch (replacement, reduction and refinement) underpins all workthat is undertaken. /n/n What you will be doing /n/n As a BRF GeMSResearch Scientist at the Crick, you will: /n/n /n/t - Assist inthe design, generation of reagents and validation of newgenetically modified alleles. /n/t - Perform core molecular biologytechniques including LR-PCR, PCR, digital droplet or qPCR,molecular cloning, NGS sequencing technologies, genotyping andsequence analysis. /n/t - Maintenance of mESC cultures and performin vitro CRISPR facilitated and classical gene targeting experimentusing electroporation, nucleofection and lipofection. Engage in outof hours cell culture work rota. /n/t - Participate in the creationof new animal models, taking a lead role towards the development ofa subset of projects; working towards agreed deadlines, identifyingand troubleshooting at each step, seeking support when required./n/t - Maintain records, ensuring your own scientific work isalways carried out accurately and efficiently, adhering to legalframeworks. /n/t - Awareness and promotion of all relevant healthand safety guidance and legislation. /n /n/n About you… /n/n Youwill bring…. /n/n /n/t - A degree or equivalent in a biologicalsubject. /n/t - Experience in a relevant position, particularly inmolecular biology and mammalian cell culture. /n/t - UnderstandingCRISPR-CAS9 design and associated techniques. /n/t - Experience ofusing genome browsers, DNA analysis software and CRISPR CAS9 guideon/off target specificity software. /n/t - Commitment to continuedprofessional development (CPD). /n/t - Experience of contributingeffectively to the work of a team with a flexible and collaborativeapproach. /n /n/n To see the complete Job Description click herefor more info /n/n About Working at the Crick… /n/n Our values /n/nEveryone who works at the Crick has a valuable role to play inadvancing the Crick’s mission and shaping our culture! /n/n /n/t -We are bold. We make space for creative, dynamic and imaginativeideas and approaches. We’re not afraid to do things differently. /n/n/n /n/t - We are open. We’re highly collaborative andinteractive, and make sure our activities are visible to theoutside world. /n /n/n /n/t - We are collegial. We show respect forone another, work cooperatively and support the wider community. /n/n/n At the Francis Crick Institute, we believe that diversity andinclusion are essential to driving innovation and scientificdiscovery. We are committed to creating a workplace where everyonefeels valued, respected, and empowered to succeed, regardless oftheir background, identity, or personal circumstances. We activelyencourage applications from individuals of all genders,ethnicities, abilities, and experiences. We want to ensure thateveryone can apply and be part of our recruitment processes and sowe'll make reasonable adjustments if you need them - just let usknow when you apply. If you need assistance with applying (i.e.,would like to apply by phone or post) please email: /n/n To find out more about life at theCrick click here. /n/n What will you receive? /n/n At the FrancisCrick Institute, we value our team members and are proud to offeran extensive range of benefits to support their well-being anddevelopment: /n/n /n/t - Visas: Applicants for this role will beeligible for sponsorship to work in the UK /n /n/n /n/t - GenerousLeave: 28 days of annual leave, plus three additional days overChristmas and bank holidays. /n /n/n /n/t - Pension Scheme: Definedcontribution pension with employer contributions of up to 16%. /n/n/n /n/t - Health & Well-being: /n /n/n /n/t - 24/7 GPconsultation services. /n /n/n /n/t - Occupational health servicesand mental health support programs. /n /n/n /n/t - Eye carevouchers and discounted healthcare plans. /n /n/n /n/t - Work-LifeBalance: /n /n/n /n/t - Back-up care for dependents. /n /n/n /n/t -Childcare support allowance. /n /n/n /n/t - Annual leave purchaseoptions. /n/t - Crick Networks offering diverse groups’ support,community and inclusive social events. /n /n/n /n/t - Perks: /n/n/n /n/t - Discounted gym memberships, bike-to-work scheme, andshopping discounts. /n /n/n /n/t - Subsidised on-site restaurantand social spaces for team interaction. /n /n/n /n/t - Development& Recognition: Comprehensive training, mentoring, and a paystructure with performance-linked progression. /n