Job summary

This advert is for a Band 7 Senior Clinical Scientist post in the Synnovis Inherited Metabolic Disease (IMD) and Newborn Screening (NBS) laboratories. These laboratories are in the Biochemical Sciences department, currently located at St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, but soon to move to the Blackfriars Hub site. This full-time permanent post offers an exciting and unique opportunity for an individual to continue their development and experience in these specialist areas of Clinical Biochemistry.

The successful candidate will work as a member of the team responsible for the development and delivery of a range of mass spectrometry and chromatography-based techniques as well as FTIR and RT-PCR, used to aid screening, diagnosis and monitoring of genetic diseases in metabolic pathways.

Candidates will have experience of working in Laboratory Medicine, including an MSc in Clinical Biochemistry, and experience of analytical and clinical validation of results and manual sample preparation techniques. Comprehensive knowledge of Screening and Metabolic Biochemistry above and beyond the MSc specification is desirable but not essential, as extensive training in analytical, interpretive and clinical aspects is provided. Attainment of FRCPath is encouraged and supported by Synnovis and the department.

Candidates who are not yet HCPC-registered but are working towards or will soon obtain registration are welcome to apply.

Main duties of the job

The main duties of the post holder may include, but are not limited to:

- Routine participation in the Metabolic and NBS Duty Scientist rotas and attendance at the Metabolic multi-disciplinary team meetings

- Interpretation and reporting of complex metabolic results including organic acids, amino acids, acylcarnitines, very long chain fatty acids, purines/pyrimidines and renal stones

- Authorisation of NBS results and participation in the weekend NBS rota

- Undertaking manual routine assays in the lab if and as required, in accordance with documented standard operating procedures

- Use of the Quality Management System, including identifying, recording and troubleshooting errors, writing and reviewing documentation, and participation in the departmental audit schedule

- Routine involvement in review or IQC and EQA results including participation in interpretative metabolic EQA schemes

- Helping identify and troubleshoot analytical and clinical issues as they arise

- Training and teaching of work experience students, clinical colleagues, visitors to the department and STP trainees completing their metabolic rotation

- To ensure compliance with good work practices in accordance with the standards of UKAS (ISO 15189) and the UKNSPC National Newborn Screening Programme Standards

About us

Your development and learning

You will have a suite of learning opportunities available through The Synnovis Way Development programme, the Scientific Learning and Development Fund and the Synnovis Academy through which you can receive funding / support for advanced qualifications.

Through our Innovation Accelerator Fund, you can apply for finance to get that new innovative scientific project off the ground, and participate with the wider scientific community through symposiums, conferences and other peer group meetings.

Job description

Job responsibilities

1.Clinical service

To safely handle blood, urine, faeces, other body tissue, hazardous and or radioactive chemicals.

ensure that appropriate preventative maintenance has been carried out on laboratory instruments and equipment prior to them being used for patient investigations.

To ensure that reagents are prepared, stored and used according to manufacturer and laboratory procedures.

To perform complex manual, semi-automated and fully-automated laboratory investigations.

To measure and monitor the accuracy and imprecision of laboratory investigations using appropriate quality control procedures.

To undertake validation of the results from laboratory investigations to ensure accuracy and precision as specified by laboratory quality procedures and protocols.

To take corrective action when quality control or assurance procedures indicate loss of performance of the laboratory instruments or methods.

To take appropriate action when there is a situation which may or has caused a service delivery failure.

To troubleshoot faults in complex laboratory instruments including dismantling and reassembly of fine parts where necessary.

To perform highly complex specialist assays.

undertake method and laboratory instrument evaluation as directed by the Lead Scientist.

Provision of clinical and scientific advice to clinicians on the appropriateness and choice of biochemical investigations and their interpretation.

To be aware of current developments relevant to the section.

To check and validate work produced by staff within the laboratory.

To interpret laboratory results and take appropriate actions in line with laboratory policies and procedures. authorisation of results, ordering relevant follow-up laboratory procedures, adding technical and clinically relevant comments, initiating action as appropriate or referring results for an expert opinion or clinical interpretation if necessary. Informing the requestor of clinically significant results.

1.16Provide approved departmental information and advice to other healthcare professionals, patients and the public and to refer on to appropriate specialists requests for information out with their area of responsibility.

To interpret the results of highly complex analytical procedures, advising on the clinical significance of these results, suggesting further investigations from a range of possibilities and initiating further action as appropriate.

meet regularly with other members of the multidisciplinary metabolic medicine team to discuss the investigation and follow up of complex clinical cases.

post holder may be required to participate in departmental clinical and analytical rotas, including out of hours cover and weekend rotas.

2.Management and Administration

keep records up to date and to ensure that all records and documentation are maintained properly.

To comply with local and national policies for the safe, secure and confidential processing, and storage of patient and other labratory information.

To use the Laboratory Information System according to the authorised protocols.

To maintain the integrity and accuracy of laboratory databases.

To develop systems and processes for recording and storing laboratory information. Including the design, maintenance and adjustment, where necessary, of databases and spreadsheets.

To ensure compliance with good work practices in accordance with the standards of UKAS (ISO 15189) and the UKNSPC National Newborn Screening Programme Standards

To prepare and review laboratory policies and procedures following national and local quality system guidelines.

prepare and review laboratory policies and procedures in connection with the specialised regional services of the section.

To ensure that all results are reported within the agreed turnaround time, and to take appropriate action, including communicating with colleagues and managers and adjusting staff deployment etc. within section in the event of assay failure.

To supervise the work and monitor performance of Medical Laboratory Assistants, Trainee Clinical and Biomedical Scientists, Biomedical Scientists and Specialist Registrars in the procedures for which the post holder is responsible.

3.Teaching and Training

participate in teaching and training personnel from the department, hospital and to the wider community.

participate in providing scientific and clinical information for departmental, local and national meetings.

train and develop the competence of Medical Laboratory Assistants, Trainee Clinical and Biomedical Scientists, Biomedical Scientists, Clinical Scientists and Specialist Registrars in the procedures for which the post holder is responsible.

4.Research and Audit

Under the guidance of other Clinical Scientists, to independently carry out research projects in line with the needs of the service.

To participate in clinical audit

assist other Clinical Scientists in preparing and monitoring management and operational performance data, for example turnaround times, workload and materials consumption, plan and take corrective action if required.

To prepare statistical reports for use in section meetings, for internal and external education and for the monthly, annual and quarterly statistics required by the UKNSPC and the newborn screening commissioners.

5.Additional Duties and Responsibilities

To comply with the policies and procedures of Viapath.

To observe and adhere to local and national risk management and health and safety policies.

To ensure that the workplace and workbenches are kept clean and tidy.

To maintain good work relations with all members of staff, and to promote effective teamwork.

treat everyone associated with Guys & St Thomas Hospital NHS trust and Viapath with dignity, courtesy and respect.

To observe national and local guidance on patient and commercial confidentiality.

Keep appropriate records of all communications.

To ensure compliance with all local and national standards of work practice UKAS (ISO 15189).

maintain and promote the professional image of Biochemical Sciences, Viapath and Guys & St Thomas Hospital NHS Trust.

The post holder may be required to participate in departmental clinical and analytical rotas, including out of hours cover.

Synnovis is a pathology partnership between SYNLAB UK and Ireland, and the NHS, including sites, Guys & St Thomas NHS Foundation Trust and Kings College Hospital NHS Foundation Trust, to deliver and transform pathology services across South East London. The partnership provides services to million people living in South East London, as well as to hundreds of thousands of patients from outside the region who use local healthcare services. The partnership provides diagnostics, testing and digital pathology for hospital trusts, GP services and other healthcare providers.

Guys and St Thomas Hospital Foundation Trust is a major emergency and specialist teaching Trust which has all the specialties associated with a fascinating and career defining case load including: Womens Services, Fetal Medicine, Haematology, Oncology, Transplantation, and is also home to the Evelina Childrens Hospital and the Cancer Centre on the Guys site. You will be close to the vibrant Borough Market and the South Bank, which are exceptional London locations; perfect places to work and relax next to such iconic venues as Big Ben, The London Eye and The Shard!

Person Specification

Qualifications

Essential

BSc in Biochemistry or related subject MSc in Clinical Biochemistry State Registered Clinical Scientist (Health and Care Professions Council)

Desirable

FRCPath (part 1) PhD in Biochemistry, Chemistry or related subject

Experience

Essential

Experience of working in a Clinical Biochemistry department, including interpretation and validation of patient results Manual sample preparation techniques Method development and validation

Desirable

Experience of working in Metabolic Biochemistry and/or Newborn Screening laboratories Routine use of LC-MS/MS or other chromatographic techniques Teaching/training of scientific, medical and technical staff

Skills & Knowledge

Essential

Organisational skills Understanding of analytical techniques, including undertaking complex analytical procedures Proven ability to work under pressure Written and verbal communication of technical information and results with clinical and scientific staff of all grades

Desirable

Knowledge of the UKAS standard and its application in a clinical laboratory