Jobs

Scientist - Upstream Process Development


Job details
  • Charles River Laboratories, Inc.
  • Keele
  • 4 days ago

At Charles River, we are passionate about improving the quality of people’s lives. When you join our global family, you will help create healthier lives for millions of patients and their families. 


Charles River employees are innovative thinkers, who are dedicated to continuous learning and improvement. We will empower you with the resources you need to grow and develop in your career. 


As a Charles River employee, you will be part of an industry-leading, customer-focused company at the forefront of drug development. Your skills will play a key role in bringing life-saving therapies to market faster through simpler, quicker, and more digitalized processes. Whether you are in lab operations, finance, IT, sales, or another area, when you work at Charles River, you will be the difference every day for patients across the globe.
 

Job Summary

We are currently recruiting for an Upstream Scientist to join our MSAT team at our manufacturing facility. The successful candidate will be responsible for the execution of client projects and internal development programs, working alongside the other Upstream scientists within the department.

 

This role is Full Time and fully onsite in Keele, Staffordshire.

Profile and Requirements

Key duties and responsibilities include but aren't limited to:

 

  • Performing Microbial upstream processing including fermentation of up to 30L scale.
  • To execute and complete Small scale (shake flasks and Ambr® system) pre-production evaluations.
  • To assist with Kit purification of plasmid DNA up to giga prep scale.
  • To execute the generation of Microbial cell banks.
  • To provide In-process analytics (productivity/purity).
  • To ensure documentation is generated for protocols, study plans and study reports in a timely manner, and to a high standard as per Charles River policies, as assigned.
  • To support with the development/continuous improvement of techniques / processes within the MSAT team and other areas of the business.


Qualifications and Key requirements: 

 

  • A degree in Biology, Biotechnology, Biochemistry or equivalent scientific qualification.
  • Previous practical laboratory experience in Upstream Processing is essential.
  • Previous experience with basic laboratory techniques, including aseptic processing is essential.
  • The ability to demonstrate a strong understanding of cGMP manufacturing
  • Able to demonstrate strong written and verbal communication skills. 
  • The ability to work as part of a team and independently as required
  • Be able to work under the pressure of client and business milestones and needs. 

About Corporate Functions 
The Corporate Functions provide operational support across Charles River in areas such as Human Resources, Finance, IT, Legal, Sales, Quality Assurance, Marketing, and Corporate Development. They partner with their colleagues across the company to develop and drive strategies and to set global standards. The functions are essential to providing a bridge between strategic vision and operational readiness, to ensure ongoing functional innovation and capability improvement.

 
About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
 

With over 20,000 employees within 110 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 
 

 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.

 

At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to the principle of diversity and inclusion and work daily in this direction.

 

For more information, please visit www.criver.com.
 

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