Scientist - Infectious Diseases - OxfordImmunocore(NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptorbiotechnology company whose purpose is to develop and commercializea new generation of transformative medicines which address unmetpatient needs in oncology, infectious diseases and autoimmunedisease. Our leaders in R&D are internationally recognised assome of the biotech industry/'s most successful drug developers. Weare creating not just an environment where great minds can interactbut an innovation powerhouse answering the big questions. Focusedon delivering first-in-class biological therapies to patients, wehave developed a highly innovative soluble TCR platform. Our ImmTAXmolecules underpin a new generation of precision engineered drugsthat harness the immune system to treat a broad spectrum ofdiseases with high unmet medical need, including oncology,infectious diseases and autoimmune diseases. At Immunocore, werecognize that our employees are our greatest asset. We value theunique contributions each person brings to our team. By embracingScience, Trust, Respect, Integrity, Diversity, and Entrepreneurship(STRIDE), we create an environment where collaboration thrives,ideas flourish, and transformative changes happen. STRIDErepresents more than just letters; it embodies our shared identityand drives our mission. We are dedicated to developing breakthroughtherapies that transform patients/' lives, advancing medicine, andsupporting one another in these pursuits. Immunocore is proud to bean equal opportunity employer. As such, we are committed tofostering an inclusive workplace where everyone feels valued,respected, and empowered. We encourage applications fromindividuals of all backgrounds, regardless of race, color,religion, sex, sexual orientation, gender identity or expression,pregnancy, age, national origin, disability status, or any othercharacteristic protected by law.The primary purpose of this role isto contribute to cross functional efforts focused on applying theImmTAX® platform or other modalities to the development of noveltreatments for chronic infections, including HIV and HBV andEBV-associated diseases. The team is involved in multiple stages ofthe drug discovery and development process, from target discoveryall the way to clinical trials. Examples of key preclinicalresearch are published in Yang H et al., Mol Ther. 2016; 24,11;Fergusson J et al., Hepatology 2020; 72,5; Wallace Z et al., MolTher 2024; 32, 678.The postholder will plan, design and executeexperimental investigations to support the advancement of theCompany pipeline, processes and technology capabilities, withguidance from their manager, ensuring that project goals are metwithin time and budget constraints. They will be expected todemonstrate technical proficiency, rigour in assessing their owndata and that of others, scientific creativity and independentthought. This position requires participation and presentation ofresults at internal meetings, sharing information learned atexternal scientific meetings and establishing productiverelationships with colleagues across Research and otherdepartments.Key Responsibilities: * With instruction and guidancefrom manager - plan, design, and execute assignments to meetproject goals within defined timeframes* Execute experiments toaddress key scientific questions and enable project progression,utilizing range of molecular and cellular techniques including someof the following: NextGen sequencing, DD-PCR, qPCR, cell culture,flow cytometry, ELISpots, ELISAs,* Some work will be conducted in acontainment level 3 (CL3 facility) and will require handling ofhuman viruses* Analyse data, interpret results, and makerecommendations* Proactively expand scientific/technical knowledgein relevant fields including HIV/HBV/EBV related disease biologyand drug development through review of scientific literature/conference updates, peer to peer mentoring, and attendance atseminars/conferences in line with company strategy* Workeffectively in a matrixed team structure and as part of crossfunctional teams * Participate and present results at internalmeetings* Establish relationships and possible collaborationswithin and outside of the companyEducation, Experience andKnowledge: Essential Qualifications: * PhD in molecular biology,cell biology, genomics, virology, immunology, or related disciplineand 0-2 years related experience* Alternatively, a BSc or MSc withsignificant work experience in relevant scientific areas * Workedin a bench-based laboratory environment and proficient inthefollowing key techniques:o molecular techniques including some ofthe following: Droplet Digital PCR, NextGen sequencing,Genomics/Transcriptomics, PCR, Mutagenesis, qPCRo Culturing primarycells and/or cell linesPreferred Qualifications:Knowledge/expertise of Immunology/HIV/HBV/EBVFlow cytometry,ELISAs, ELISpots * Viral integration site analysis
