Job type: Full-time
Location:Oxford, with hybrid working options available
Salary:Competitive salary
Right to work:Sponsorship available
Application deadline: 21st February 2025
Application submission:CV and cover letter via our websitewww.omass.com/working-here/
OMass Therapeutics is a biotechnology company based in Oxford discovering medicines against highly- validated target ecosystems, such as membrane proteins or intracellular complexes. The company’s unique OdyssION™ technology platform comprises novel biochemistry techniques, next-generation native mass spectrometry, and custom chemistry. OMass is advancing a pipeline of small molecule therapeutics in rare diseases and immunological conditions, that target solute carriers, complex-bound proteins, and GPCRs.
We are seeking a Preclinical Toxicologist (Principal Scientist/Associate Director DOE). You will be part of a dynamic andinnovativeenvironment and will become an integral part of our vision to address patients’ unmet needs while building Britain’s Biggest Biotech. You will use your preclinical expertise and scientific curiosity to solve drug discovery and development challenges, as part of multi-disciplinary project teams. You will be able to work in state-of-the-art laboratory and modern facilities for optimumcollaborationalongside afocusedandcaringteam.
You will already have a high degree of knowledge in preclinical safety assessment studies supporting IND-enabling packages and relevant regulatory requirements. In addition to possessing several years’ experience in managing safety assessment studies either as Sponsor Monitor, Deputy Study Director or Study Director level.
To find out more about the meaningful work OMass delivers, as well as our EVP you can find this herehttps://www.omass.com/
Requirements
Essential Experience, Skills and Qualities
- A degree or equivalent in Biology, Toxicology, Biomedical Science, Pharmacology or related pharmaceutical science
- Significant amount of relevant industry, biotech or CRO experience with a track record of contributing to study designs and interpretation of data.
- High degree of knowledge in preclinical safety assessment studies supporting IND-enabling packages and relevant regulatory requirements
- Experience in managing safety assessment studies either as Sponsor Monitor, Deputy Study Director or Study Director level.
- A strong knowledge of regulatory guidelines on study conduct
- High level of analytical and problem-solving skills, and the ability for lateral thinking
- Responsible and focused approach to independent and collaborative work, with the ability to prioritise and deliver high quality work to deadlines.
- Innovative and ambitious mindset, with an inquisitive and agile approach to problem-solving and overcoming technical challenges; motivated to continuously learn and take on challenges.
- Caring and inclusive; respectful and receptive to others’ diverse ideas, experience and perspectives, and enjoys working collaboratively with others as a team.
- Excellent communication skills, both written and verbal with high attention to detail.
Preferred Experience and Skills
- Experience at Study Director/Deputy Study Director level and/or Sponsor Monitor in preclinical toxicology and safety pharmacology studies supporting IND-enabling packages
- Experience in exploratory/investigative preclinical toxicology
- Toxicokinetic analysis/experience in the use of Phoenix WinNonLin
- Ability to navigate and work effectively in a fast-paced, matrix-team work environment
- Experience in managing and working with external contract research organisations
- A creative and strategic thinker who can enthuse the DMPK and Toxicology group and the wider OMass team with innovative ideas
- Strong organisational skills with an ability to prioritise work accordingly to project goals and take responsibility for the timely delivery of objectives
Role Responsibilities
- Provide expertise in preclinical studies to support a range of drug development projects working from Candidate Selection and beyond
- Work with the Development team and Director of DMPK/Toxicology to resolve or risk-mitigate project-related safety challenges in the design and optimisation of drug discovery molecules
- Design, commission and conduct appropriate experimental studies to support compound development nomination, project progression
- Act as Sponsor Study contact/co-ordinator for day-to-day correspondence between specialist CROs and OMass development programs
- Be involved in vendor visits to aid selection and build collaborative approaches
- Design preclinical toxicology/safety pharmacology through specialist contract research organisations
- Interpret data and write and present project reports
- Share information openly and work collaboratively with other departments to help advance different projects and achieve company goals
- Promote and adhere to OMass’ values of being Ambitious, Responsible, Innovative, Focused, Caring and Collaborative
Benefits
OMass offers an excellent benefits package including:
- Private Health Insurance
- Health and wellbeing cashback scheme
- Life Assurance and Income Protection
- Participation in Employee Equity Scheme
- 25 days annual leave, plus bank holidays
- Pension Scheme offering 6% employer contribution
- Learning and Development Opportunities
- Company social events
Any queries relating to the role can be sent to .
OMass Therapeutics values diversity and is committed to equality of opportunity, we also have full responsibility to ensure that all employees are eligible to work and live in the UK.
