Postdoctoral Fellow – J. M. Adrover lab

About us
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role
Dr. Adrover’s laboratory focuses on how cancer affects whole-body physiology, with a particular emphasis on the cardiovascular, haematopoietic, and immune systems.

The Cancer Macroenvironment Lab is seeking applications for postdoctoral candidates to carry out experimental work aimed at understanding the interplay between cancer and the haematopoietic compartment. The research program will study how cancer affects the haematopoietic stem and progenitor cell compartment to induce changes in myeloid populations that then have detrimental roles in cancer progression. You will be looking at how this happens and how we can target these processes to enhance cancer patient’s welfare.

You will be mainly working in a wet lab, although the role will also encompass sequencing data analysis.

What you will be doing
As aPostdoctoral Fellowat the Crick, some of your main responsibilities will be:

- Using murine models of cancer to analyse the hematopoietic stem and progenitor cell compartment in the bone marrow to understand neutrophil differentiation dynamics and how they are affected by growing tumours.

- Studying the precise mechanisms through which cancer communicates with the bone marrow compartment, with the goal of targeting these processes to enhance patient welfare.

• Interrogating how cancer therapy affects haematopoietic stem and progenitor cells. In broader terms, exploring contexts other than cancer in which similar reprogramming of the hematopoietic compartment takes place.
• Using state of the artin vivointravital imaging as well asex vivotissue clearing techniques to study bone marrow niche dynamics.
  
  The project can be tailored to the interests of the successful candidate. Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.
  
  About you
  You will bring
  
  - PhD in immunology, cancer biology, biochemistry or cell biology or in the final stages of PhD submission
• Knowledge and experience in stem cell biology, immunology or cancer biology
• Technical expertise in mouse work, and experience with experimental design
• Flow cytometry and microscopy experience
• Track record of writing papers as evidenced by publications in peer-reviewed journals
• Evidence of data presentation at scientific meetings
• Ability to work independently and collaborate with others
  
  About Working at the Crick
  Our values
  Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!
  
  - We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
  
  - We areopen. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
  
  - We arecollegial. We show respect for one another, work cooperatively and support the wider community.
  
  At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post)please email:
  
  What will you receive?
  At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:
  
  -Visas:Applicants for this role will be eligible for sponsorship to work in the UK
  
  -Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
  
  -Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
  
  -Health & Well-being:
  
  - 24/7 GP consultation services.
  
  - Occupational health services and mental health support programs.
  
  - Eye care vouchers and discounted healthcare plans.
  
  -Work-Life Balance:
  
  - Back-up care for dependents.
  
  - Childcare support allowance.
  
  - Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.
  
  -Perks:
  
  - Discounted gym memberships, bike-to-work scheme, and shopping discounts.
  
  - Subsidised on-site restaurant and social spaces for team interaction.
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