MRC Postdoctoral Research Scientist LMS 2646

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MRC Postdoctoral Research Scientist LMS 2646, London

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Client:

Medical Research Council
Location:

London, United Kingdom
Job Category:

Other
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EU work permit required:

Yes
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Job Reference:

72b3fff56781
Job Views:

4
Posted:

29.06.2025
Expiry Date:

13.08.2025
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Job Description:

Overall purpose:
We are looking for a talented postdoctoral research scientist to work on a project in cancer metabolism and transporter biology in the Drug Transport and Tumour Metabolism group (headed by Louise Fets), at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London.
We have interests in both cancer metabolism and pharmacology/drug distribution, with a particular focus on the role played by membrane transporters at the intersection between these two fields (Alam et al., DMM, 2023, Moncayo et al., BioRXiv, 2025). We have previously shown that transporter-dependent drug accumulation can have implications for drug response (Fets et al., Nat Chem Biol, 2018; Comms Biol, 2022). It is clear that transporters also shape metabolism, and their heterogeneous expression at both the inter-patient and intra-tumoural level can also have knock-on implications for drug response in cancer. With guidance from Dr Fets, the successful candidate will develop and lead a project that explores at the mechanistic level how transporter-driven metabolic changes influence drug response and drive drug resistance in cancer.
The ideal candidate will have a background in cancer metabolism, cellular metabolism, transporter biology and/or related fields. Prior experience in metabolomics and cancer cell biology are highly desirable. The position is available to be filled summer 2025, but the candidate is required to be in post by end of September 2025.
To plan and carry out research in accordance with the project aims
Take initiatives in the planning of research
Write reports for submission to research sponsors
Submit publications to refereed journals
Provide guidance to staff and students
Contribute to bids for research grants
Conduct and plan own scientific work with appropriate supervision
Maintain highly organised and accurate record of work
To attend project and related research group meetings
To interact and collaborate with group members
Write-up and publication of work in peer-reviewed journals
To take an active part in the academic activities of the LMS
To attend and contribute to journal clubs and seminar presentations
Presentation of data at national and international meetings
To form good working relationships with other members of the group as well as internal and external collaborators
To assist others and co-supervise students when required
/*generated inline style */ Person Specification

Overall purpose:
We are looking for a talented postdoctoral research scientist to work on a project in cancer metabolism and transporter biology in the Drug Transport and Tumour Metabolism group (headed by Louise Fets), at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London.
We have interests in both cancer metabolism and pharmacology/drug distribution, with a particular focus on the role played by membrane transporters at the intersection between these two fields (Alam et al., DMM, 2023, Moncayo et al., BioRXiv, 2025). We have previously shown that transporter-dependent drug accumulation can have implications for drug response (Fets et al., Nat Chem Biol, 2018; Comms Biol, 2022). It is clear that transporters also shape metabolism, and their heterogeneous expression at both the inter-patient and intra-tumoural level can also have knock-on implications for drug response in cancer. With guidance from Dr Fets, the successful candidate will develop and lead a project that explores at the mechanistic level how transporter-driven metabolic changes influence drug response and drive drug resistance in cancer.
The ideal candidate will have a background in cancer metabolism, cellular metabolism, transporter biology and/or related fields. Prior experience in metabolomics and cancer cell biology are highly desirable. The position is available to be filled summer 2025, but the candidate is required to be in post by end of September 2025.
Main duties / key responsibilities:
To plan and carry out research in accordance with the project aims
Take initiatives in the planning of research
Write reports for submission to research sponsors
Submit publications to refereed journals
Provide guidance to staff and students
Contribute to bids for research grants
Conduct and plan own scientific work with appropriate supervision
Maintain highly organised and accurate record of work
To attend project and related research group meetings
To interact and collaborate with group members
Write-up and publication of work in peer-reviewed journals
To take an active part in the academic activities of the LMS
To attend and contribute to journal clubs and seminar presentations
Presentation of data at national and international meetings
To form good working relationships with other members of the group as well as internal and external collaborators
To assist others and co-supervise students when required
/*generated inline style */ Person Specification

Education / Qualifications / Training required (will be assessed from application form):
Essential:
A PhD (or equivalent experience) in cancer metabolism, cellular metabolism or a related biological field
Desirable:
A first-author publication, preprint, or manuscript in preparation for imminent submission
Previous work experience required (will be assessed from application form and at interview):
Essential:
Evidence that the candidate can plan and carry on a research project
Extensive wet lab experience in techniques relating to at least one of: metabolic approaches, cell biology, molecular biology
Desirable:
Expertise in GC-MS or LC-MS metabolomics, especially if in combination with stable isotope labelling
Experience immunofluorescence and live cell imaging
Interest in and proven experience of developing or implementing new techniques in the lab
Experience in handling and bioinformatics analysis of ‘omics datasets
Evidence of actively contributing to or driving scientific collaborations
Knowledge and experience (will be assessed from application form and at interview):
Essential:
Excellent written communication skills in English
A strong interest in cancer metabolism and transporter biology
Demonstration of creative approaches to problem solving
Desirable:
Strong publication record and exposure to scientific meetings
Personal Skills / Behaviours / Qualities (will be assessed at the interview):
Essential:
Ability to conduct reproducible research
Ability to conduct a detailed review of recent literature
Ability to develop and apply new concepts
Creative approach to problem-solving
Excellent verbal communication skills in English and the ability to deal with a wide range of people
Ability to organise own work with minimal supervision
Ability to prioritise own work in response to deadlines
Willingness to work as part of a team and to be open-minded and cooperative
Flexible attitude towards work
Discipline and regard for confidentiality and security at all times
Willingness to work out of normal working hours if the requirements of the project demand
Willingness to undertake any necessary training for the role
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