Lead Full-stack Engineer (UK)

Fully remote | Top quartile salary | Stock options

We are hiring a lead engineer to co-own the technical execution of a collaborative, self-service, cloud-based platform that leverages predictive models and complex data to explain drug efficacy and toxicity. Fully remote.

The role

• Lead the engineering of the Syntensor platform, a first-of-its-kind collaborative, self-service platform for improving the efficiency of the drug discovery process
• Prepare our platform to scale; iterate on and improve the platform’s architecture and its associated services and databases
• Develop data visualization approaches for multimodal biomedical data, with a focus on pathway and network visualization
• Own the development of the Syntensor user-facing app, a large React application
• Architect and develop the app backend, presently developed with Node.js on AWS
• Define and build strong foundations to your own high standards - CI/CD processes, devops, monitoring and scaling, and security
• Collaborate closely with the head of product to determine the technical design of new features in the user-facing product
• Work with a small hands-on team - you’ll work with machine learning researchers to shape overall system architecture and integrations with ML systems (Python/Pytorch, Geometric Deep Learning)
• Make fundamental business impact - you will take an active role in shaping our product, creating a strong engineering culture and building a highly skilled and focused team
• Competitive compensation - A starting salary in the top quartile for role and level, based on local benchmarks
• Stock options - you are joining an early-stage startup we want you to have ‘skin in the game’ and your options package will reflect this
• Self-manage - we are a distributed-first company, working from home and collaborating asynchronously from Seattle, NY, Vermont, and Manchester
• Take on a grand challenge and share our purposeful mission - we’re building a biological systems simulator that will transform how medicines are developed - you will be making it accessible and powerful for scientists and doctors, with a big downstream impact on the wellbeing of millions of patients

About you

• Experience designing and building reliable REST APIs
• Experience with modern JS tooling and build systems
• Working knowledge of authentication, authorization and related security practices
• Experience designing data schemas and managing relation and non-relational databases (we use MySQL and ElasticSearch)
• Working knowledge of Python for data processing and API development
• Good knowledge of CSS and responsive design (we use CSS modules)
• Experience architecting and maintaining cloud infrastructure (we use AWS)
• Experience with Git, Docker and CI/CD pipelines
• Experience with asynchronous work within a remote team across multiple time zones
• Ability to self-manage in a small team environment
• English fluency, verbal and written

Nice to haves

• Familiarity with machine learning concepts and applications
• Knowledge of data visualization libraries such as D3.js or Chart.js
• Experience with unit and E2E testing (we use Cypress)
• Knowledge of modern authorization mechanisms, such as JSON Web Token
• Experience architecturing large cloud-based systems using microservices and serveless paradigm
• Experience designing pipelines and storage solutions for ML-driven systems with large volume of complex data
• Experience managing infrastructure using code-as-infrastructure paradigm - we use AWS CDK
• Experience with integration of 3rd party corporate systems or experience with work in regulated corporate settings (e.g. healthcare or finance)
• Experience interfacing with ML systems (ours is Python/Pytorch)
• Experience developing highly interactive visualizations of complex data
• Good eye for UI and knowledge best of UX principles
• Experience with Figma
• Experience with biomedical data and bioinformatics
• Experience managing and growing engineering teams
• Experience with WebGPU

About usOur mission

We are on a mission to provide access to more effective medicines for millions of patients. We’re building a model of human molecular physiology for research scientists and clinicians that can answer the fundamental question, "will it work?"

Every modernized field of engineering has a systems simulator to test complex interactions in bits rather than atoms. This doesn’t yet exist for biology. Without one, drug development is expensive because risk of failure is very high; 30-60% of prescribed medicines have no clinical benefit to patients and adverse reaction to treatment is the 4th leading cause of death in the US, ahead of pulmonary disease and diabetes. Syntensor is taking on this grand challenge, developing fundamental machine learning methods and applying them at scale to biological data so every individual patient can be prescribed the most effective, least toxic treatment possible.

What we do

We are productionizing and scaling up a generalizable machine learning platform that predicts efficacy and toxicity for any drug in any indication. We are using an extensive, heterogeneous biomedical graph, novel fundamental ML methods and advanced engineering infrastructure to generate and explain model outputs for users of our app. Currently, our users are research scientists involved in drug development.

The team

We are a small team of people with diverse skills and a shared bias towards problem solving and execution. We are inventors and builders who believe in the scientific method; feedback and iteration is essential to our process and we share our work early and often. That said, we aim high. Our mission and the domain in which we operate demand that we take on some of the hardest problems researchers, scientists, engineers and designers face, and we are determined to build technology that solves them properly and usefully for users of our platform. We are looking for talented people who are motivated by the challenge of hard problems and who are already curious about the technological, scientific or cultural domains with which we engage.

We are a distributed-first team and very relaxed about where and when work happens, but come together as a whole team weekly to sync-up. We work with intrinsic curiosity and motivation towards well defined goals (even where there are unknown unknowns). Our diversity, great communication and respectful, supportive teamwork make us highly effective.

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