This is afull-time permanentposition on Crick terms and conditions of employment.
Salary:From £49,955, subject to skills and experience, with benefits.
Application Closing date: 3rd Feb 2025.
About us…
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture.
About the role…
The Human Models Core (HMC) is an integral part of the Human Biology Facility. Operated by a team of scientific and technical experts, the HMC offers a portfolio of services and support to researchers. Working closely with the Human Biology Governance Team and research groups at the Crick, the HMC is aimed to facilitate a broad spectrum of human models research.
The HMC team is involved in developing key models for human disease by reprogramming somatic cells into pluripotent stem cell lines and assisting with downstream applications like gene editing and differentiation. Additionally, we provide and maintain a well-equipped communal laboratory space which facilitates interaction between the groups working with human models, pluripotent stem cells and gene editing.
We are seeking a highly motivated, proactive stem cell expert with deep knowledge and understanding in reprogramming pluripotent stem cells (PSC), differentiation and gene editing. The successful candidate will take the lead on reprogramming projects, support and advise on differentiation projects, gene editing projects and the generation of human 2D and 3D models.
As aPrincipal Laboratory Research Scientist, you will:
- Identify, manage and deliver robust scientific support to Crick Researchers.
- Project delivery of reprogramming portfolio.
- Support gene editing projects in PSC.
- Reprogram somatic cells to pluripotent stem cells.
- Register reprogrammed cell lines.
- Establish new methodologies in the lab.
- Develop proof-of-concept for new research directions.
- Horizon scanning and developing specific scientific projects and platforms within the facility in a collaborative setting.
- Support research groups, Head of Lab ops in grant writing and publications.
- Provide tissue culture, quality control and technical support to research groups within the Francis Crick Institute.
- Teach and train scientists in the best practice skill sets necessary to grow, characterise, differentiate and bank human pluripotent stem cells.
About you…
You will bring:
- Degree in a biological subject with substantial post-graduate experience in pluripotent stem cell research.
- PHD or equivalent experience.
- Extensive wet lab experience in pluripotent cell culture.
- Experience in reprogramming cells to pluripotency.
- Experience in PSC model development.
- Proven track record in scientific publication.
- Demonstrable experience with best practice, quality control assessment and related assays.
- Excellent communication and presentation skills.
- Excellent organisational skills and record keeping with attention to detail.
- Ability to prioritise workflows and deliver to deadlines.
- Highly self-motivated with a pro-active approach.
About Working at the Crick…
Our values
- We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
- We areopen. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
- We arecollegial. We show respect for one another, work cooperatively and support the wider community.
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences.
What will you receive?
At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:
- Visas -The Crick offers funding for those requiring a visa to work in the UK.
- Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
- Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
- Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans.
- Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options.
- Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction.
- Development & Recognition: Comprehensive training, mentoring, and a pay structure with performance-linked progression.
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