In Vivo Scientist - Avian Specialist

Job Description Agenda are looking for a driven InVivo Scientist to spearhead the creation of advanced transgenicavian models for biologic discovery in one of our facilities inCambridge. This role entails hands-on work with live animals,focusing on the derivation, cultivation, manipulation, andmicroinjection of primordial germ cells (PGCs), alongside the careand management of transgenic birds. The ideal candidate willcollaborate closely with a multidisciplinary team of molecularbiologists and discovery specialists, leveraging their expertise todrive forward this impactful project in collaboration with aprominent pharmaceutical company. /n/n Responsibilities /n/n /n/t -Isolate, culture, and manipulate primordial germ cells (PGC) forgenetic modifications. /n/t - Transfect PGCs with targeting vectorsand DNA editing reagents. /n/t - Isolate monoclonal cell lines andensure their characterization for downstream applications. /n/t -Perform microinjections to introduce modified PGCs into recipientembryos with precision. /n/t - Collaborate on genetic modificationstrategies like CRISPR/Cas9 and homologous recombination. /n/t -Manage avian transgenic colonies and implement breeding strategiesfor maintenance. /n/t - Work with cross-functional teams to designtailored transgenic strategies for biologic discovery. /n/t -Ensure compliance with UK government regulations for animal welfareand biosafety, including obtaining necessary permits for researchand transport. /n /n/n Qualifications: /n/n /n/t - Education: PhDin Genetics, Molecular Biology, Developmental Biology, or a relatedfield. Candidates with a Master’s degree and extensive relevantexperience will also be considered. /n/t - Experience:/n/t /n/t/t -Hands-on experience with genome-editing techniques, particularly inavian or non-mammalian species. /n/t/t - Proficiency in workingwith PGCs, including their derivation, cultivation, manipulation,transfection, and isolation of monoclonal cell lines. /n/t/t -Familiarity with molecular biology techniques such as PCR, qPCR,cloning, and sequencing. /n/t/t - Experience in generating andcharacterizing transgenic animal models (Avian species). /n/t/t -Previous work with avian species in a laboratory setting /n/t /n/t/n/t - Skills:/n/t /n/t/t - Strong analytical and problem-solvingskills. /n/t/t - Excellent communication and collaborationabilities. /n/t/t - Proficiency in data analysis and bioinformaticstools is a plus. /n/t /n/t /n /n/n Preferred Qualifications: /n/n/n/t - Experience with large-scale genetic screening orhigh-throughput editing approaches. /n/t - Familiarity with UKregulatory requirements for transgenic animal research. /n/t -Personal license for in vivo work with birds (Avian PIL A). /n/t -Willingness and ability to travel to the animal facility located inthe Cambridge area as needed. /n /n/n Agenda and its clients onlyrecruit people who are passionate about animal care and welfare,people with integrity who are honest and trustworthy and who have agreat work ethic. To enable us to hire the very best people, wewill conduct a comprehensive background and pre-employmentscreening, an essential part of Agenda's recruitmentprocess.