Higher Scientific Officer - Drug Discovery Biology, Centre for Protein Degradation, Sutton

Higher Scientific Officer - Drug Discovery Biology, Centre for Protein Degradation, Sutton

Client:The Institute of Cancer Research

Location:Sutton, United Kingdom

Job Category:Other

EU work permit required:Yes

Job Reference:0aeac9ba045a

Job Views:6

Posted:11.03.2025

Expiry Date:25.04.2025

Job Description:

We are seeking to recruit a Higher Scientific Officer within the Induced Proximity Therapeutics (IPT) Team in the ICR Centre for Protein Degradation to support our molecular glue and PROTAC drug discovery projects and expand induced proximity technology. The IPT team focuses on three main areas of research:

1. Cancer target validation
2. Screening, profiling and molecular mechanism of action of molecular glue and PROTAC degraders
3. Novel E3 ligase biology and ligand discovery

The successful candidate will work in a multidisciplinary team and play a key role in target validation, developing in vitro and cell-based assays, and pharmacological characterization of novel molecular glue degraders and PROTACs, but may also contribute to other activities.

About You

The successful candidate:

1. Will be a strong team player who is technically minded and passionate about science and cancer drug discovery
2. Will hold a first degree, and preferably a PhD, in biological science or biochemistry
3. Will have experience in cancer biology/target validation, genetic manipulation techniques, in vitro and cell-based assay development and pharmacological compound profiling

Experience in targeted protein degradation will be a significant advantage.

Department/Directorate Information

This position will be based in the ICRs Centre for Protein Degradation, a part of the Centre for Cancer Drug Discovery (CCDD) specializing in developing novel drug modalities that re-wire tumor cells signaling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists, oncology specialists, and physicians on discovering new medicines - molecular glue degraders and PROTACs - using innovative screening platforms and characterizing their mechanisms of action, as well as expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation). Our research provides a nucleus for the academics and pharmaceutical industry to explore the therapeutic potential of targeted protein degradation from laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients.

What We Offer

1. A dynamic and supportive research environment in one of the successful academic cancer drug discovery centres in the UK
2. Access to state-of-the-art facilities and professional development
3. Collaboration with leading drug discovery and oncology scientists
4. Competitive salary and pension

To learn more about this role, please download the attached job pack. For informal inquiries, please contact Dr. Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation via email: [emailprotected].

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