Jobs in Leeds

Head, PV and Regulatory QA

This role leads the global quality and compliance function for pharmacovigilance (PV) systems, ensuring adherence to international regulations and internal standards across clinical safety, regulatory affairs, and medical affairs. The position combines strategic oversight with hands-on operational leadership, including audit strategy, inspection readiness, deviation and CAPA management, and cross-functional GxP guidance. It requires deep technical expertise in PV processes and strong leadership to drive quality across global teams and third-party vendors.

CSL

Head, PV and Regulatory QA

Leads global pharmacovigilance and regulatory quality assurance, ensuring compliance with GVP, ICH, and regulatory standards across clinical safety, medical affairs, and regulatory affairs. Designs audit strategies, manages inspections, and oversees deviation management, CAPA, and change control systems. Provides cross-functional GxP expertise and drives continuous improvement in PV quality systems.

CSL

Precision Medicine Director

The role involves leading the development and execution of precision medicine strategies within global clinical programs, focusing on biomarker and diagnostic initiatives for patient selection and regulatory support. It requires close collaboration with cross-functional teams and external partners, ensuring compliance with medical device regulations and high-quality scientific delivery. The position is embedded in the Neuroscience disease area, emphasizing strategic input into clinical trial design and regulatory submissions.

Novartis London, United Kingdom

Hybrid Permanent

Precision Medicine Director

The Precision Medicine Director leads the development and execution of biomarker and diagnostic strategies within global clinical programs, focusing on patient selection and regulatory-aligned trial design. This role acts as a scientific expert, guiding cross-functional teams in neuroscience-focused initiatives and ensuring compliance with medical device regulations. The position emphasizes strategic leadership in precision medicine, with strong collaboration across clinical development, diagnostics, and external research partners.

Novartis Ardross, Alba / Scotland, IV17 0YF, United Kingdom

Hybrid Permanent

Senior Medical Director Early Clinical Respiratory

This role involves leading early-phase clinical development in respiratory therapeutics, designing and overseeing Phase 1 and 2a trials, and translating scientific innovation into clinical proof-of-concept. The individual will act as a medical expert, shaping clinical strategies, guiding regulatory interactions, and mentoring teams within a global, collaborative environment. Emphasis is placed on biomarker use, translational research, and engagement with external scientific leaders.

AstraZeneca Cambridge, United Kingdom

Executive Director, Strategy, Oncology R&D

This role involves leading the global Oncology R&D strategy at AstraZeneca, shaping therapeutic area priorities by integrating clinical, scientific, and commercial insights. The individual will advise senior leadership on portfolio optimization, investment decisions, and strategic trade-offs, using rigorous analysis to drive innovation and patient impact. It requires influencing without authority, aligning cross-functional teams, and maintaining strategic rigor across complex R&D landscapes.

AstraZeneca London, United Kingdom US$270,222 – US$405,332 pa

On-site Permanent

Director, Regulatory Affairs

Lead global regulatory strategy and execution for drug development programs, ensuring compliance across jurisdictions including the US, EU, and UK. Collaborate with cross-functional teams to prepare and manage regulatory submissions such as INDs, NDAs, and orphan drug designations. Provide strategic guidance on regulatory risks and lifecycle management, while engaging with health authorities and shaping regulatory science in the context of AI-driven drug discovery.

Recursion North Tyneside, NE29 8EP, United Kingdom £207,500 – £280,720 pa

Remote Permanent

Director, Regulatory Affairs

Lead the development and execution of global regulatory strategies for drug discovery programs, ensuring compliance across jurisdictions including the US, UK, and EU. Collaborate with cross-functional teams to manage regulatory submissions, engage with health authorities, and support clinical development from IND-enabling stages through approval and lifecycle management. Drive regulatory innovation by applying AI-driven platforms to accelerate drug development pathways.

Recursion United Kingdom £111,100 – £141,800 pa

Finance Portfolio Analytics Manager

This role involves building and leading the analytical framework for R&D investment decisions at a global biopharma company. The Finance Portfolio Analytics Manager designs financial models, valuation tools, and dashboards to translate scientific and clinical data into quantified financial impact. They lead strategic analyses, improve forecasting methodologies, and provide data-driven insights to senior leadership across complex portfolio decisions.

GSK

Sr. Manager, Global Regulatory Science CTA

Lead the end-to-end operational execution of Clinical Trial Applications (CTAs) outside the US, ensuring regulatory compliance and timely submissions across global markets. Serve as the subject matter expert on UK clinical trial regulations, including MHRA requirements and evolving legislation, while leveraging digital tools and AI-enabled technologies to enhance regulatory operations. Collaborate with cross-functional teams and CROs to maintain inspection-ready documentation and drive continuous improvement in regulatory processes.

Moderna Poland

On-site Permanent

Sr. Manager, Global Regulatory Science CTA

Lead the operational execution of Clinical Trial Applications (CTAs) globally outside the US, with a focus on compliance, submission excellence, and cross-functional coordination. Serve as the subject matter expert for the UK clinical trial regulatory landscape, including MHRA requirements and evolving legislation. Leverage digital platforms and AI-enabled tools to enhance regulatory operations and submission efficiency across international markets.

Moderna

On-site Permanent

SERM Scientific Director

Leads safety evaluation and risk management for GSK's oncology assets in clinical development, providing scientific expertise to assess and communicate safety risks globally. Works cross-functionally to shape safety strategy, support regulatory submissions, and ensure patient protection. Focuses on signal detection, risk assessment, and strategic decision-making in a matrix environment.

GSK £111,750 – £186,250 pa

On-site Permanent

Sr. Manager, Operational Strategy Lead

This role involves developing and implementing end-to-end clinical supply operational strategies for Pfizer's global clinical programs, focusing on packaging, labelling, and distribution. The Operational Strategy Lead works cross-functionally to ensure patient-centric, compliant, and efficient delivery of clinical supplies, while driving continuous improvement and digital transformation in supply chain processes. Key responsibilities include risk management, stakeholder collaboration, and strategic planning to support clinical trial timelines and patient needs.

Pfizer

Director, Pharmacovigilance

Leads global pharmacovigilance and safety strategy for gene therapy products, overseeing signal management, risk assessment, and benefit-risk profiling across investigational and marketed phases. Provides medical oversight for clinical trials, including safety data review, SAE evaluation, and regulatory submissions. Collaborates cross-functionally to ensure compliance with global safety regulations and supports health authority interactions on product safety matters.

Orchard Therapeutics London, United Kingdom

Hybrid Permanent

Regulatory Scientist

Supports regulatory strategies for gene therapies, focusing on post-approval lifecycle management in EU/UK markets and expansion in ROW regions. Prepares and reviews submissions, manages labelling updates, and responds to regulatory queries. Monitors regulatory intelligence and contributes to SOPs and audit readiness.

Orchard Therapeutics London, United Kingdom

Hybrid Permanent