Biotechnology Jobs

• London
• Hybrid · 3 days in office
• Senior

Drive DMPK strategy across drug discovery projects, designing screening cascades and mechanistic experiments while integrating AI/ML and PBPK modelling to predict human dosing, efficacy and safety windows. Work within an interdisciplinary team of drug design and machine learning specialists, authoring regulatory documents and optimising molecule design with chemistry leads.

R · Python · KNIME

• USA - Pennsylvania - Upper Providence
• Hybrid
• US$188,100 – US$313,500 pa
• Director

Leads model-informed drug development for oncology programmes, defining and executing model-based strategies from late candidate selection through life cycle management. Conducts population PK, exposure-response and simulation-based trial design work across small molecules, biologics and antibody drug conjugates, applying AI/ML and quantitative systems pharmacology methods. Presents and defends modelling outcomes to governance boards and regulators, and contributes to protocols, analysis plans and submissions.

NONMEM · R

• Durham Blackwell Street
• Hybrid
• US$188,100 – US$313,500 pa
• Director

Leads model-informed drug development for oncology programmes, defining and executing model-based strategies from late candidate selection through life cycle management. Conducts population PK, exposure-response and simulation-based trial design work, applying AI/ML and quantitative systems pharmacology methods, and defends results to governance boards and regulators. Sits within a matrixed Clinical Pharmacology Modelling and Simulation group working across small molecules, biologics and antibody drug conjugates.

NONMEM · R

• London
• On-site
• Director

Shape global CMC regulatory strategy for an innovative mRNA medicines portfolio, driving international submissions and health authority interactions. Prepare and review CMC sections of regulatory filings, advise Manufacturing and Quality teams, and oversee multiple development programs. An individual contributor role with global reach, working alongside teams using digital and Generative AI tools.

Generative AI

• London
• Hybrid · 3 days in office
• Director · manages people

Lead all externalised drug discovery and preclinical laboratory activities, designing and scaling a modern CRO infrastructure for an AI-first drug design platform. Oversee experimental throughput, data quality control and turnaround times, and embed data-generation-by-design standards with external partners. Manage a team of CRO Scientific Leads, Operations Managers and Compound Managers, and shape long-term sourcing strategies with DDMR leadership.

AlphaFold

• London
• Hybrid · 3–4 days in office
• Director

Lead CMC regulatory strategy for UK-manufactured and UK-licensed mRNA products across development, registration and post-approval lifecycle. Act as primary point of contact with the MHRA, oversee submissions and manufacturing change assessments, and shape global regulatory approaches across cross-functional matrix teams.

MHRA · Generative AI

• New York, United States
• Hybrid · 2–3 days in office
• US$151,800 – US$220,660 pa
• Senior

Integrates phenomics, transcriptomics, genomics and proteomics data to nominate and validate oncology targets and define precision oncology patient strategies. Partners cross-functionally with biologists, chemists, engineers and translational experts to build target data packages and pilot novel discovery methods, including agentic target packages and mechanism-of-action work.

CRISPR

• London
• US$268,000 – US$384,000 pa
• Lead

Conducts original computational biology research for AI safety, investigating how LLMs, specialised biological models, agents and automated laboratories combine to change what is biologically feasible. Spans protein and nucleic-acid design, cellular systems and biological delivery, translating risk judgments into dual-use policy boundaries, evaluation priorities and mitigation requirements alongside threat modellers and red-teamers.

LLMs · Agents · Automated Laboratories +1

• Cambridge
• On-site
• £45,000 – £50,000 pa
• Senior
• Permanent

Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.

CRISPR/Cas9 · Recombinase-Mediated Cassette Exchange · Bxb1 +3

• Saffron Walden
• Hybrid
• £3,452 – £3,861 pm
• Contract

Curate molecular interaction and macromolecular complex data from scientific literature and user depositions into the IntAct and Complex Portal knowledgebases. Work with bioinformaticians and developers to build curation workflows combining expert manual curation with AI-assisted literature mining, using ontologies and community data standards.

IntAct · Complex Portal · Gene Ontology +2

• Remote Opportunity - United States
• Remote
• Lead

Join a cross-functional team of scientists, engineers and drug hunters advancing frontier AI research and end-to-end applications across drug discovery, design and translation. Work spans large datasets, multimodal models and a unifying biomedical world model bridging virtual patient and virtual cell, with rapid iteration in an AI-native TechBio environment.

• London
• Hybrid
• Junior
• Permanent

Hands-on business development role researching pharma and biotech accounts, writing outreach, and owning CRM pipeline hygiene in HubSpot. Works directly with founders and the head of sales, building sales materials and AI workflows while coordinating with the science team ahead of customer meetings.

HubSpot · LinkedIn

• London
• Hybrid
• Senior
• Permanent

Architect novel generative models to design functional proteins, working in an interdisciplinary team of ML researchers, protein engineers and biologists. Split roughly 90/10 between building and evaluating models against wet lab results and self-development, with heavy emphasis on data pipelines, cloud training and production-quality code.

NeurIPS · ICML · ICLR

• Saffron Walden
• Hybrid · 2 days in office
• £4,395 pm
• Lead · manages people
• Contract

Lead the scientific data programme behind FENIX, a unified platform for archiving and exploring functional genomics datasets. You will line manage bioinformaticians and curators, own data standards and quality controls, and guide reproducible Nextflow workflow development while acting as principal scientific liaison with teams such as ENA, Ensembl and UniProt.

Nextflow · Python · R +7

• Exeter
• Entry level
• Contract

A cross-institutional PhD studentship analysing whole genome sequencing data from millions of individuals across UK Biobank, All of Us and Our Future Health to identify rare causal variants for musculoskeletal disorders, then functionally validating them in human cell and tissue models using CRISPR-Cas9, transcriptomics and cellular phenotyping. Split between computational genomics at Exeter and laboratory work at Oxford, it develops a dual skill set in statistical genetics and experimental validation.

UK Biobank · All of Us · Our Future Health +4