Scientist I – Molecular Biology

About the Role

As a Molecular Biologist in the GEO (Genetically Engineered Organisms) Team, you will contribute to the design and construction of large-scale synthetic gene loci that underpin our next-generation discovery platforms. Using advanced genome engineering approaches, you will help create highly diverse systems for therapeutic antibody discovery, including bispecifics and VHHs. This role blends thoughtful genetic design with hands-on experimental work to build the scientific capabilities that enable our partners to develop new medicines.

You will utilise the latest technologies and equipment to develop and characterize next-generation research models, supporting the discovery of innovative therapeutics and helping others make better medicines.

Why This Role Is Unique

You will join the Genetically Engineered Organisms (GEO) team and work alongside the broader Alloy ecosystem, including our Antibody Division, 82VS, Bioinformatics, and our extensive network of partners and collaborators. Our team's goal is to develop innovative transgenic platforms to support antibody discovery efforts both internally and for our external partners, ultimately delivering the best medicines to patients.

We are a small, diverse team bringing together a wide range of expertise in genetics, molecular biology, and cellular biology. By working closely with internal colleagues and external partners, we develop next-generation platforms that drive drug discovery research. Supported by various functional groups and a strong network of collaborators and consultants, the GEO team thrives in a highly collaborative, multidisciplinary environment.

Responsibilities

How You’ll Drive Impact

• Complex Locus Engineering:Design and implement complex humanization strategies using state-of-the-art technologies to model the human immune repertoire across diverse research platforms.

• Quality Control:Apply rigorous scientific judgment to ensure consistency and reliability by critically evaluating data, experimental approaches, and conclusions.

• Innovation:Approach scientific challenges with curiosity and an open mindset, contributing new ideas and methods while fostering collaborative problem-solving.

• Execution:Take initiative and proactively advance work, demonstrating ownership and accountability while contributing to team success.

• Collaboration & Trust:Build strong working relationships by consistently delivering high-quality work, acting with integrity, and supporting shared team goals.

How You Work

• Accountability & Drive:You thrive in a nimble, startup-style environment, owning projects from the initial "dry lab" design to the final "wet lab" validation.

• Attention to Detail:You apply meticulous attention to detail in scientific thinking and written documentation, and communicate and present information with clarity and precision.

• Proactive Approach:You are eager to learn and support the team, bring an independent sense of urgency, and drive projects forward through persistence and a commitment to integrity.

Required Qualifications

• Education:PhD in Developmental Biology, Functional Genetics, Molecular Biology, Immunology, Cell Biology or a related discipline, or equivalent industry experience (your title will be aligned with your experience).

• Immunology:Knowledge of immunology and the ability to perform immunophenotypic analysis of B and T cell populations using multicolor flow cytometry.

• Genetic Engineering:Familiarity with genetic engineering and the generation of transgenic animal models, including the design of targeting and screening strategies, vector construction and preparation, data analysis and troubleshooting.

• Precision Genome Engineering:Proficiency in CRISPR/Cas9 and advanced integration tools, such as Recombinase-Mediated Cassette Exchange (RMCE) or site-specific integrases (e.g., Bxb1).

• Molecular Biology:High proficiency in molecular biology techniques such as PCR, western blotting, next-generation sequencing (NGS), plasmid construction and nucleic acid purification.

• Comparative Immunogenetics:A good understanding of human immunology and repertoire generation mechanisms across different species, specifically how to engineer for both V(D)J recombination and alternative diversification strategies like gene conversion or somatic hypermutation.

• Model Characterization:Experience with the functional validation of new in vivo models, including flow cytometry, cell sorting, and the assessment of serum titers/binder affinity.

• Animal Science:Foundational knowledge of animal physiology, husbandry, and genotyping.

• Software:Working knowledge of, and the ability to quickly learn, software packages such as Geneious Prime, Benchling and FlowJo

Benefits

We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.

Compensation

• Competitive base and equity compensation commensurate with level of experience and independence

Health & Wellbeing

• Comprehensive benefits package including Private Medical Insurance with dental and optical cashback, pension contribution matching, Group Income Protection, Group Life Assurance, and mental health and wellbeing support.

Unique Perks

• 25 annual leave days (with one additional day for every 3 years completed, up to 27 days)

• Annual stipend for continuing education with commitment to your career through an individualized professional development plan

Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at. We will make every effort to respond to your request for disability assistance as soon as possible.