Location: Science Creates St Philips, Bristol, UK (On-site full time)
Position: Full Time (37.5 hours/week)
Salary: £(phone number removed) per annum (pro rata) dependent on experience
About Carbometrics
Carbometrics is a specialist chemistry company based in Bristol, UK. Our core competency is the design, synthesis and derivatisation of highly selective and robust carbohydrate-binding molecules. Our mission is to help people with diabetes to live more normal and longer lives. We are using our proprietary Biomimetic Glucose Binding Molecules (GBM) to develop a new glucose sensor chemistry that will enable market-leading Continuous Glucose Monitors (CGM).
Our technology is based on over 20 years of cutting-edge research, pioneered by Professor Anthony Davis’ group at the University of Bristol (see: Davis et al., Nature Chemistry, 11, 52-56, 2019). Carbometrics’ goal is to exploit our GBM technology to realise a highly robust and accurate glucose sensing platform that can be used to create a market-leading Continuous Glucose Monitoring (CGM) solution. The company was set up after the founders sold their first company, Ziylo, to Novo Nordisk, which is using the same platform to develop smart insulins.
About the role
In the last 12 months, Carbometrics has developed and optimised an assay for the quantitation of glucose in aqueous media and in vivo applications. Attention is now being turned towards the sensing of other analytes of clinical significance. The successful candidate will be using their synthetic chemical, analytical and problem-solving skills to synthesise and modify a variety of molecules ranging from small molecules to larger macromolecules such as functional polymers, proteins and RNA/DNA. To thrive in this role, the candidate must be able to work independently, be adaptable to new ideas and change, be resourceful and self-motivated. The role is based within our innovative team in Bristol’s only dedicated scientific incubator: Science Creates. Carbometrics is a young, growing company and will offer the successful candidate an interesting and enjoyable work environment with a highly motivated team of scientists plus an opportunity to grow and develop scientific skills and experience.
Job Description:
As a Senior Scientist in Synthetic Chemistry, you will be responsible for:
• Designing and conducting laboratory experiments in a safe and efficient manner.
• Synthesis, purification and characterisation of small molecules.
• Bioconjugation, modification, purification and characterisation of large molecules.
• Analysing experimental data using the relevant software (e.g. MNova) and maintain an electronic record of experiments (e.g. MBook).
• Using various equipment such as spectrometers (NMR, UV Vis, fluorescence, plate reader), chromatography (Biotage automated flash purification, LCMS, HPLC, size exclusion, GPC), and biophysical techniques such as Isothermal Titration Calorimetry or Surface plasmon resonance (SPR)/Bio-layer interferometry (BLI) etc.
• Contributing to scientific discussions and offering suggestions to push forward new projects.
• Ability to work within a multidisciplinary team towards larger objectives.
• Routinely present scientific data and results in a clear and concise manner, as well as communicating these effectively to the rest of the team.
What We're Looking For:
• Qualification at undergraduate or postgraduate level (Bachelor’s, Master’s, PhD) in Synthetic Chemistry.
• Extensive hands-on experience in laboratory settings and knowledge of purification and analysis methods for molecules of varying molecular weight and polarity.
• Ability to manipulate sub-milligram quantities of material.
• Experience in modification of biomolecules and bioconjugation is desirable but not essential.
• Aptitude for troubleshooting experimental issues, interpreting data, and designing alternative approaches to achieve research objectives.
• Eagerness to stay informed about new techniques, technologies, and advancements in the field of chemistry, and the ability to quickly incorporate them into practical work.
Qualifications (required):
• A BSc in an appropriate field is essential (Chemistry/Biochemistry/Chemical Engineering).
• Further qualifications in an appropriate field are desirable (MSc, PhD)
Why Join Us?
• Opportunity to work on groundbreaking technology in glucose monitoring.
• Gain valuable hands-on experience in practical chemistry, biochemistry and photo physics.
• Work in a fast-paced startup environment where your work directly contributes to the company's objectives.
• Competitive salary, flexible work terms and numerous benefits.
At Carbometrics we value diversity. We are an equal opportunities employer and welcome employees who meet the requirements of the job, regardless of gender, ethnic origin, disability, age, religion or sexual orientation.
Important information regarding your application:
Please note that we will not be confirming receipt of applications. Please include in your application confirmation of your consent for Carbometrics to hold your information and personal details for recruitment purposes. Applications without consent will be discarded.
Regarding an application, the procedure outlined will be followed:
• Carbometrics will keep records of your application strictly for recruitment purposes.
• Any recruitment documentation will be kept for 12 months following the job position being filled.
• The successful candidates’ recruitment documentation will be kept in accordance with
• Carbometrics’ Internal Personal Data Policy.
If you wish for your information to be removed from our records before that date, please contact our Head of Operations.
Closing Date: Closing date for application is Friday 29th November 2024 unless the role is filled earlier.
You may also have experience in the following: Scientist, Polymer Science, Hydrogel Chemistry, Polymer R&D, Science Analysis, Science research, Carbometric technology, chemistry, Biomedical Engineering, ATRP, RAFT, Bioconjugation, Synthetic Chemistry, Chromatography etc
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