Senior Principal AI/ML Engineer...

Job description
Site Name: UK London New Oxford Street
Posted Date: Jun 11 2025

We are seeking a Senior Principal AI/ML Engineer to join GSK R&D Digital & Tech. This role is focused on designing and deploying cutting-edge AI/ML solutions that accelerate our drug discovery and development pipeline. The ideal candidate will possess deep technical expertise in AI/ML, hands-on experience building scalable solutions, and proven ability to engage with cross-functional stakeholders including scientists, business leaders, and technical peers.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will

• Lead the design, development, and deployment of advanced AI/ML models across the R&D domain (drug discovery, genomics, clinical trials, and more).
  
• Translate complex scientific and business problems into scalable ML pipelines using state-of-the-art techniques.
  
• Collaborate with cross-functional teams including data scientists, biologists, chemists, clinical researchers, and software engineers.
  
• Drive model interpretability, scalability, and reproducibility in high-stakes biomedical applications.
  
• Drive technical decision-making around architecture, model development, and data integration.
  
• Champion best practices in MLOps, model validation, and responsible AI, especially in regulated biomedical environments.
  
• Lead initiatives focused on Generative AI and Agentic AI, developing AI agents that can reason, plan, and interact autonomously with data, tools, and systems.
  
• Mentor other engineers and data scientists; foster best practices around MLOps, experimentation tracking, and continuous integration.
  
  Why you?
  
  Basic Qualifications & Skills:
  
  We are looking for professionals with these required skills to achieve our goals:
  
  
• PhD or Master's degree in computer science, Machine Learning, Statistics, Computational Biology, or a related quantitative field.
  
• Extensive experience in AI/ML engineering.
  
• Demonstrated experience working closely with business stakeholders in R&D, translating complex scientific challenges into AI solutions.
  
• Proficiency in Python and ML libraries (e.g., TensorFlow, PyTorch, Scikit-learn, Hugging Face).
  
• Experience building and deploying models in cloud environments (e.g. Azure, GCP).
  
• Solid understanding of statistics, optimization, and experimental design.
  
  Preferred Qualifications & Skills:
  
  Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
  
  
• Prior experience in pharmaceutical R&D and drug discovery workflows.
  
• Familiarity with biomedical datasets such as omics, EHR, imaging, or clinical trial data.
  
• Familiarity with FAIR data principles, real-world evidence (RWE), or synthetic control arms.
  
• Knowledge of regulatory requirements in AI for healthcare (e.g., GxP, MHRA, EMA).
  
• Experience with LLMs or foundation models in life sciences.
  
  Closing Date for Applications 29th June 2025 (COB)
  
  Please take a copy of the Job Description, as this will not be available post closure of the advert.
  When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
  
  Why GSK?
  
  Uniting science, technology and talent to get ahead of disease together.
  
  GSK is a global biopharma company with a special purpose to unite science, technology and talent to get ahead of disease together so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
  
  Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
  
  GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
  
  We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
  
  Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or . The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.
  
  Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive .
  
  Important notice to Employment businesses/ Agencies
  
  GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
  
  Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website athttps://openpaymentsdata.cms.gov/
  
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