Senior Clinical Development Scientist

Myrixc Bio is a UK biotech Company focused on the discovery and development of a completely novel class of selective cytotoxic payloads for antibody drug conjugates (ADCs), based on inhibitors of N-myristoyltransferases (NMT) for the treatment of cancer. Myricx Bio recently announced the closing of its series A financing raising £90m ($114m), the largest of a university spin-out in Europe in 2024.

We are now looking to progress our first asset into clinic and are looking to recruit a Senior Clinical Scientist who will be responsible for the scientific oversight and execution of early-phase oncology clinical trial(s).

Role Overview;

The Clinical Development Scientist will collaborate closely with cross-functional teams, including Clinical Operations, Data Management and Biostatistics, to drive the development of novel oncology therapies. The successful candidate will have strong experience in clinical trial design, protocol development, scientific data interpretation, and CRO management, and will also be responsible for medical monitoring duties. This role requires a highly motivated, detail-oriented professional with a strong scientific background and the ability to thrive in a fast-paced, dynamic environment.

Key Responsibilities:

Clinical Trial Design and Protocol Development:

1. Lead the development of scientifically sound and operationally feasible clinical trial protocols for early-phase oncology studies.
2. Contribute to the development of clinical development plans and overall clinical strategy.
3. Collaborate with medical experts, biostatisticians, and other stakeholders to ensure the scientific rigour of trial designs.

Clinical Trial Document Writing and Review:

1. Author and revise essential clinical trial documents, including protocols, informed consent forms (ICFs), patient information sheets (PIS), and study-specific guidelines.
2. Ensure that all documents are compliant with regulatory requirements, ethical standards, and company SOPs.
3. Review and provide scientific input on clinical study reports (CSRs) and other clinical documentation.

CRO Management:

1. Serve as the point of contact for CROs, ensuring high-quality execution of clinical trials
2. Participate in CRO selection and provide input during the vendor evaluation process.
3. Participate in the management of scientific aspects of the CRO relationship including ensuring appropriate personnel and training.

International Trial Experience:

1. Contribute to the planning and execution of clinical trials in the US
2. Collaborate with clinical teams, CROs, and investigators to ensure effective study conduct across diverse settings.

Data Analysis and Interpretation:

1. Collaborate with biostatisticians and data managers to analyse emerging clinical trial data.
2. Interpret/present scientific data from ongoing clinical trials to inform decision-making and identify potential issues.
3. Prepare and present data summaries and reports to internal and external stakeholders, including data safety monitoring boards (DSMBs).
4. Review clinical trial databases to identify trends and address any data issues.

Medical Monitoring and Safety Oversight:

1. Contribute to the medical monitoring of clinical trials, including review of safety data.
2. Collaborate with the project medical monitor and safety teams to identify and evaluate any potential safety signals.
3. Participate in safety data reviews and contribute to the management of serious adverse events (SAEs).

Scientific Expertise:

1. Maintain knowledge of the current literature in relevant therapeutic areas.
2. Engage in continuous learning to stay up-to-date on emerging trends in cancer research and treatment.

Requirements:

• BSc or MSc in Life Sciences (e.g. biology, pharmacology, or related studies).
• Considerable experience in clinical research or clinical development within the pharmaceutical or biotechnology industry
• Demonstrated experience in early-phase development, including executing Phase I/II Oncology clinical trials
• Experience with regulatory submissions (INDs)
• Excellent scientific writing and proven ability to lead the development of clinical documents including trial protocols, ICFs, PIS, and other.
• Strong experience working with CROs
• Experience managing or overseeing clinical trials in international regions-specifically the US
• Knowledge of GCP, ICH guidelines.
• Strong understanding of clinical trial methodology, data analysis, and scientific interpretation.
• Experience with EDC systems, CRFs and other clinical trial technologies.

Desirable skills:

1. Experience with oncology treatment modalities-(e.g., Antibody Drug Conjugates, immunotherapy, targeted therapies, cell therapies, chemotherapy).
2. Experience with various therapeutic areas in oncology, and knowledge of cancer biology.

What’s in it for you? Why work at Myricx Bio

We are a small but rapidly growing team, with a vision to advance a pipeline of ADCs based on our novel NMT inhibitor (NMTi) payload chemistry platform to address serious unmet needs in oncology. As an early joiner, you will have a unique opportunity to help shape our trajectory and make real impact from day one.

Myricx Bio s an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.