Scientist II: Formulation

4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. We are expanding our Formulation team at our site just north of Cambridge, UK. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.

The primary focus of the role is R&D formulation development of our non-viral delivery platform and delivery of non-viral formulations for client and collaborator projects.

Responsibilities:

• R&D of non-viral delivery platform - formulation, characterisation and validation of novel nanoparticles for gene delivery based on end needs of the formulations
• Preparation and characterisation of non-viral nanoparticles for client or collaborator projects
• Actively participate and contribute to laboratory and company meetings
• Maintain an accurate and complete record of laboratory work performed
• To use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines
• To undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested

Person Specification:

• Master’s degree in Chemistry, Biochemistry, biochemical engineering or related discipline
• Experience working in a scientific laboratory a must.
• Experience in nanoparticle production, characterization (e.g. DLS, electron microscopy, SAXS or SANS) and downstream process (e.g. purification, sterilization, long-term storage) techniques.
• Knowledgeable and/or willingness to discuss molecule level chemistry. Molecular modelling, chemical synthesis or analytical chemistry knowledge desirable
• Experience in Design of Experiments (DoE) and statistical data analysis is desirable
• Experience in microfluidic technologies
• An understanding of the basics with an interest in current global development activities and research in gene therapy and nano-scale drug delivery technologies
• Experience/knowledge on the handling of nucleic acids and related testing techniques (e.g. gel electrophoresis, nucleic acid quantification assay) desirable
• Great communication and presentation skills
• Self motivated and willing to learn new skills
• Must hold right to work in the UK

What we offer:

Competitive salary + comprehensive benefits package

Location:

This role is located in Over, North of Cambridge

We are unable to offer sponsorship for this role.

Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.