Scientist Analytical Development - Oxford

Scientist Analytical Development - OxfordImmunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry\\s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients\\ lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.To characterise the companies biotherapeutic recombinant T-cell receptor based and related molecules using a wide variety of protein characterisation and mass spectrometry methods. To contribute to the development of characterisation methods for the company\\s biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass spectrometry analysis. KEY RESPONSIBILITIES* Supporting drug substance and drug product impurity characterisation and identification* Performing protein sequence and post translational modification identification, including glycosylation analysis. * Supporting drug substance and drug product process development by performing characterisation of process intermediates * Contribute to the development of characterisation methods for ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis * Contribute to writing study protocols and reports.* Priorities: Planning and working to agreed experiment deadlines, schedules and objectives; advising managers and colleagues of risks and deviations.* Technical Knowledge: Proactively seeking to expand scientific knowledge through individual learning, peer to peer mentoring, and line managerial support. * Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.* Laboratory equipment: Understand how to use equipment most effectively.* Reporting: Communicating and presenting research findings at meetings with colleagues, senior management and partners.* Adhere to safe working practices in laboratories according to Immunocore EHS policies.PERSON SPECIFICATIONExperience & knowledgeEssential* A background in recombinant protein or antibody analytical development or QC, with 2 or more years\\ experience gained in industry. * Experience in development of HPLC based methods of recombinant proteins or antibodies. * Experience of LC-MS method development* Worked in a bench-based bio-pharmaceutical/biochemistry laboratory environment with a recognized and established expertise in:o Selection and design of buffers and reagents implementation into working practises o Routine laboratory procedures i.e. pH, conductivity and spectrometry and troubleshooting unexpected findingso Established as an expert amongst peers in one or more of the following areas:  electrophoretic  chromatographic  mass spectrometry* Familiar with principles of assay qualification/ validation i.e. robustness and suitability * Familiar with the principles of Good Manufacturing Practise (GMP)* Recorded results in a concise and timely way, and in compliance with agreed standards* Learnt about new practices through observation, self-learning and an enquiring mind * Worked and contributed actively in a diverse team environmentDesirable* Understanding of stability studies principles and interpretation thereof* Experience of glycosylation analysis of recombinant proteins* Method development and transfer to or receipt from external parties * Presented at conferences* Understanding of analytical requirements to support materials for use in clinical trialsEducation & qualifications* Essential: BSc. Or MSc. in biochemistry, biotechnology or related discipline* Desirable: PhD in related discipline