We are recruiting highly motivated research technicians to participate in a new academic-industrial global initiative supported by the Michael J Fox Foundation for Parkinson's Research. The project aims to: (1) Explore and validate new approaches to target LRRK2; (2) Perform systematic mechanistic, structural and safety analyses to benchmark new LRRK2 modifiers that emerge from this effort and (3) identify clinically relevant biomarkers for LRRK2-driven Parkinson's disease that will facilitate the selection of patients who respond to LRRK2 inhibitor therapy. We aim to galvanise research and accelerate the development of Parkinson's disease therapeutics. These positions enable further training in state-of-the-art methods through the course of the project, and involve wider collaboration with Protein Phosphorylation and Ubiquitylation Unit members, other academic Institutions worldwide and industrial partners working in this area.

The appointed post holder will be based within the laboratories of Dario Alessi, Esther Sammler and Paul Davies within the University of Dundee's MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU,http://www.ppu.mrc.ac.uk/).

The successful applicant will have previous knowledge and expertise in one or more of the followingareas:

1. Mechanistic cell biology employing a multidisciplinary approach including molecular, biochemical, physiological, mass spectrometry, pharmacological and genetic methodologies.
2. Screening and characterisation of compounds in in vitro and in vivoassays.
3. Proteinpurification.
4. Structuralbiology.
5. Computational and AI modelling for hit discovery andoptimisation.
6. Biophysical assays to investigate protein/protein interactions and for compoundscreening.

7. Quantitative mass spectrometry analysis (proteomic, lipidomic, metabolomic, post translational modifications), preferably in clinical samples.

8. Bioinformatic methodologies and analysis of large datasets including mass spectrometrydata.

Your priorities willinclude:

• • To undertake research in the relevant discipline area using the appropriate methods and/ortechniques.
  • To support the production of research reports and/or publications as required by the funding body or for dissemination to the wider academic community.
  • To collaborate with research colleagues and support staff internally as appropriate to theresearch.
  • To undertake any other duties relevant to the programme of research asrequired.

Who we're lookingfor:

• • Previous hands-on experience in one or more of the following: biochemistry, mass spectrometry, cell biology, molecular biology, structural biology, signal transduction, data analysis and bioinformatic analysis.
  • Hand-on experience in experimental techniques and data analysis that are relevant to therole.
  • Knowledge and interest in understanding pathways that are linked to neurodegeneration and Parkinson'sdisease.
  • Ability to work in a team in a highly collaborative manner, embracing the principles of OpenScience.
  • Excellent interpersonal and organisationalskills.
  • Excellent knowledge of the English language isessential.

Additional requirements for Grade 6 positionsinclude:

• • MSc in a relevantdiscipline.
  • Experience in independent researchprojects.
  • Experience in multi-institutional and/or industry collaborations is highlydesirable.

For further information about this position please contact please contact Prof. Dario Alessi(),Dr Esther Sammler(), Dr Paul Davies()or Dr Francesca Tonelli().To find out more about MRC PPU please visithttps://www.ppu.mrc.ac.uk/