We are looking for a talented and motivated postdoctoral scientist to join the lab of Professor Sir Steve Jackson (), based in the internationally renowned Cancer Research UK Cambridge Institute , located on the Cambridge Biomedical Campus, Cambridge, UK.

DNA in our cells is frequently subject to a wide array of molecularly distinct forms of damage. To cope with this, life has evolved multiple DNA repair and associated processes, collectively termed the DNA-damage response (DDR). While considerable progress has been made in identifying DDR components and their regulators, much remains to be learned about how they operate and are controlled.

We are seeking candidates who can build on successful recent work in our laboratory to:

Identify novel genetic and functional relationships between DDR genes/proteins, and between these and other cellular components, thereby providing fundamental insights into how mammalian cells respond to DNA damage and defining how such responses are controlled and coordinated. Expand our knowledge of how DDR processes are affected by protein post-translational modifications, particularly ubiquitylation and phosphorylation. Establish how defects and deregulation of certain DDR processes affect cellular sensitivity and resistance to established and emerging cancer therapies; and identify the potential clinical relevance of these affects in cancer and/or genetic diseases caused by DDR deficiencies.

The work will be multi-disciplinary, combining recently established genome engineering and genetic screening approaches in human or mouse cells with next-generation sequencing, bioinformatics, cell biology, molecular biology and biochemistry.

Essential criteria

Candidates are expected to be largely independent and highly motivated and must have a PhD in biological sciences or be close to completing their postgraduate degree. Candidates should have strong experience in mammalian cell biology and CRISPR-based gene editing technologies. While projects in the lab benefit from access to expert bioinformaticians within the group, some knowledge of bioinformatics is desirable. Applicants should have excellent written and spoken English communication skills and demonstrate excellent organisation.

You will play key roles in a highly collaborative research programme, within the context of a large, vibrant and interactive research group, so a collaborative, friendly and collegial attitude is essential.

Fixed-term: The funds for this post are available for 1 year in the first instance.

The closing date for applications is Friday 8th November, with interviews expected to take place shortly after this date.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38, £32,982) moving to Research Associate (Grade 7) upon confirmation of their PhD award.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.