Role Summary

The post holder will be highly motivated and organised, with knowledge of cell and gene therapy, process development and biotechnology. Required technical skills include molecular biology, cell culture and analytical methods such as flow cytometry, ELISA and qPCR. They will closely collaborate with other team members and contribute to the development of processes suitable for manufacture and analysis of high-quality cell-based products.

Key Responsibilities

 Work as part of team to develop and/or optimise cell-based potency analytical procedures.

 Perform regular maintenance of suspension/adherent cells in culture, cell counting using automated cell counter. Support team in generation and maintenance of cell banks.

 Undertake method qualification/validation as per project requirements.

 Perform regular instrument maintenance (when required)

 Attention to detail, maintain accurate and clearly written laboratory notebooks.

 Perform regular stock check of reagents and consumables.

 Compile development reports and Standard Operating Procedures (SOPs).

 Assist in technology transfers including providing training on the analytical procedure (s) as per project requirements. 

The post-holder will be responsible for adhering to all health and safety guidance provided by the company.

Demonstrated skills and competencies E – Essential P – Preferred Experience

 Hands-on experience with the culture of mammalian cells, both adherent and suspension. (E)

 Immaculate aseptic technique. (E)

 Hands-on experience with cell-based assays and techniques relevant to viral vector biology – (transfection, transduction, flow cytometry). (P)

 Experience with flow cytometry. (P) Qualifications

 MSc (P)/BSc (E) educated or equivalent in Immunology, Biology/Biochemistry or related discipline with relevant industry or academic experience (P) Skills/Specialist knowledge

 Good understanding of immunology and cell biology. (E)

 Familiar with good laboratory practices. (E)

 Ability to present results clearly and logically. (E)

 Proactive and flexible personality with enthusiasm to learn. (E)

 Good attention to detail and ability to accurately follow SOPs and protocols. (E)

 Comfortable to work in a fast-paced industry environment. (E)

 Proficient in MS Word, Excel, Power Point, DOE and any other relevant applications. (E)

 Understanding of and familiarity with regulatory guidance governing cell-based and biopharmaceutical development. (P)