R&D Technologist

Job title: R&D Technologist
Location: Cambridge
Contract Length: 12 months
Working Hours: 37.5 hours/week
Pay Rate: £15.83

About the Role

Opportunity to work in the cutting edge of R&D in the biopharmaceutical industry at a globally leading CDMO.

Key Responsibilities

Contribute to the delivery of new mammalian expression hosts and vector systems for the expression of complex therapeutic proteins.
Engineer mammalian cell lines (e.g. Stable cell line generation, targeted integration and gene editing - e.g. CRISPR-based systems).
Generate mammalian expression vectors using state of the art assembly techniques.
Phenotypic characterisation of edited cell lines with relevant assays (e.g. NGS, ddPCR, qPCR and flow cytometry) and cell culture techniques (e.g., shake flask/ bioreactor).
Collate, analyse, evaluate and sign-off data to produce good quality information and traceable records under the direction of the project lead.
Presentation of results in written and oral reports.
Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein expression (in particular with R&D Process Development & Protein Analytics)
Actively keep abreast of relevant academic literature (e.g., in the field of cell engineering and expression technologies).
Contribute ideas and opinions to scientific discussions to aid the development of new technologies.
Working both individually and as a team player - working with a high degree of flexibility.
Execute studies in support of technology or process development projects.
Supports development of study plans.
Maintains accurate and timely records to appropriate quality standards for self and team, prepares high quality data summaries.

Key requirements:

BSc/MSc Degree in Life Sciences / Science/ Molecular Biology
Practical experience within in an industrial/academic setting is desirable.
Good technical background in molecular biology (Electrophoresis, PCR, vector construction) and cell culture (preferably mammalian cells) with the aim of developing or manipulating mammalian expression systems.
Clear demonstration of strong technical skills, scientific execution and data analysis.
A proactive attitude to working and solving challenging problems.
Good working knowledge of statistics and expertise in design of experiments.
Experience of cell line engineering, ideally with CRISPR-based systems would be an advantage and highly desirable.
Good understanding of synthetic biology technologies would be desirable.

Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy