Principal Scientist – Multiplexed assays of variant effects (MAVE)

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Principal Scientist – Multiplexed assays of variant effects (MAVE), Hinxton col-narrow-left
Client: Location: Hinxton, United Kingdom
Job Category: Other
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EU work permit required: Yes
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Job Reference: e1b2991fd39e
Job Views: 4
Posted: 29.06.2025
Expiry Date: 13.08.2025
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Job Description: Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.
An exciting opportunity has arisen for an experienced scientist to join the Scientific Operations team at the Sanger Institute to help define and implement a coordinated strategy for the establishment and development of technologies to study Multiplexed Assays of Variant Effects (MAVE) across the institute. This will involve identifying, developing, designing and testing potential solutions for functional genomics tools that fulfil unmet scientific or technical needs; supporting the implementation of appropriate technologies and the maintenance of high-quality outputs by operational teams.
About the Role:
You will join a multi-disciplinary team working highly collaboratively with faculty teams, research groups and existing experts to implement and utilise cutting-edge emerging technologies for CRISPR-based functional genomics. You will contribute to the MAVEscience of the institute, which is a growing area over the next 5-year funding cycle and beyond.

You will be responsible for:
Helping to develop and implement a strategy to support the development of the current and next generations of techniques, instruments and methodologies in the rapidly growing area of MAVE and functional genomics to meet the demands across the institute.
Providing support, education and training to Operational staff.
Keeping abreast of the rapidly advancing technology landscape and assess this against the needs of the institute to provide expert input into the development of future research.
About You:
You will need to have excellent communication and relationship-building skills to integrate multiple research and operational teams and will need to deal with rapid shifts and changes in complex technical requirements as projects develop and priorities change. It is also critical that you can design, implement and troubleshoot experiments and identify areas of improvement.

In addition, you will need:
Extensive and demonstrable experience working in an applied research or technical development environment
Extensive in-depth understanding and proven experience in functional genomics i.e. molecular biology/genetics, gene editing including CRISPR and/or sequencing technology
Ability to build and maintain relationships and inspire confidence and respect at all levels; a strong team player
Experience in designing and delivering technical development projects of high complexity
Detailed and extensive working knowledge of applied research methods (e.g. statistical analysis, experimental design, good research practice).
About Us:
Scientific Operations comprises the Institute’s scientific facilities across sequencing, cellular biology, spatial genomics, flow cytometry, tissue culture, gene editing, sample preparation and management, and associated research and development activities. These activities are facilitated by project and relationship management, quality assurance and business administration teams. We collaborate with programme research scientists to develop new techniques and build new platforms to translate ambitious experimental ideas into everyday reality. The post holder will be based within Cellular Operations, but will work closely with Sequencing Operations, SciOps R&D teams and the Adams and Hurles teams who are experts on MAVE technologies and their applications to research in the areas of cancer and developmental disorders.

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