Principal Investigator - Remote UK

Barrington James
Birmingham
6 months ago
Applications closed

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About the Role

We are seeking a dedicated and experienced Principal Investigator (PI) to join our expanding UK clinical research team. This is a hybrid position, combining remote medical oversight with regular on-site responsibilities across our network of clinical research sites. The PI will act as the medically accountable lead for assigned studies, ensuring trials are conducted to the highest scientific, ethical, and regulatory standards while safeguarding participant safety.


Key Responsibilities


Medical & Regulatory Oversight

  • Serve as the Principal Investigator for clinical trials, providing overall medical leadership and accountability.
  • Ensure strict compliance with study protocols, ICH-GCP, UK Clinical Trial Regulations, MHRA guidance, and local SOPs.
  • Conduct or oversee medical eligibility assessments, patient histories, and trial-specific examinations (on-site as required).
  • Review and sign off informed consent forms, patient safety data, and study documentation.


Participant Safety & Clinical Care

  • Monitor participant safety throughout the duration of studies, making clinical decisions regarding treatment continuation or withdrawal.
  • Report SAEs, SUSARs, and AEs in accordance with regulatory timelines.
  • Act as the key medical contact for participant concerns, clinical queries, and emergency oversight.


Leadership & Collaboration

  • Provide guidance and mentorship to research staff, including sub-investigators, nurses, and coordinators.
  • Build strong relationships with sponsors, CROs, and regulators.
  • Participate in site selection, feasibility assessments, and audits.


Hybrid Work Model

  • Remote responsibilities include: protocol review, safety oversight, medical queries, and teleconferences with sponsors/CROs.
  • On-site responsibilities (at least 1–2 days per week, depending on study requirements) include: patient assessments, staff training, monitoring visits, and audits.


Qualifications & Experience

  • Medical degree (MBBS/MBChB or equivalent) with full GMC registration and licence to practise in the UK.
  • Previous experience as a Principal Investigator and Sub-Investigator required, but experienced clinicians with a strong interest in research will also be considered.
  • Solid understanding of ICH-GCP, UK Clinical Trial Regulations, and MHRA requirements.
  • Excellent leadership, communication, and organizational skills.
  • Ability to balance remote work efficiency with on-site clinical commitments.


What We Offer

  • Flexible hybrid working model (remote + site-based).
  • Opportunity to lead high-impact clinical trials across a range of therapeutic areas.
  • Professional development and training in clinical research leadership.
  • Collaborative working culture with supportive multidisciplinary teams.
  • Competitive salary and benefits package.


Key Competencies

  • Clinical expertise and sound decision-making.
  • Strong grasp of regulatory and ethical frameworks.
  • Effective communication and team leadership.
  • Adaptability to both virtual and on-site working environments.
  • Commitment to patient-centred care and research excellence.

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