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Principal Investigator

Velocity Clinical Research, Inc.
Bristol
1 month ago
Applications closed

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Sub Investigator

Junior Study Coordinator

Clinical Trial Specialist

Clinical Trial Specialist

Senior Clinical Specialist

Clinical Trial Specialist

A fantastic opportunity to join the world's leading integrated site organisation as we scale up for the future!


Competitive salary and package.



The Investigator is responsible for the conduct of the clinical trial at a trial site. Investigator responsibilities are centred around the planning, execution, management and oversight of assigned studies. The Investigator is responsible for ensuring the safety of clinical trial participants. An Investigator leads the multidisciplinary study team and must communicate succinctly and effectively with clinical trial sponsors, study directors, and site staff.


**Applicants are requested to submit a summary of clinical research trials to include; their role (Principal Investigator/Sub-Investigator), dates the study was conducted between and the location.**


Duties/Responsibilities:

  • Provide overall medical direction and medical review of protocols in conformance with the investigational plan and good clinical practice
  • Provide medical expertise and scientific feasibility for new sponsor inquiries
  • Ensure that the safety and well-being of all participants in the study at the trial site are protected
  • Ensure data collected at the study site is credible and accurate
  • Ensure the rights, integrity, and confidentiality of all participants in the trial at the site are protected
  • Assist and provide guidance to clinical operations, research staff, and to sponsor client managers as required
  • Obtain and/or review participants’ medical history
  • Perform physical assessments, examinations and study procedures as required by study protocols
  • Evaluate and interpret clinical data and diagnostic information such as X-rays, ECGs and lab work.
  • Immediately report Serious Adverse Events (SAEs)—or any abnormalities affecting participants’ safety—to sponsors as required by study specific reporting guidelines
  • Oversee the administration of Investigational Product
  • Review and adhere to study protocol
  • Maintain proper documentation
  • Ensure accuracy, completeness, legibility, and timeliness of data reported and be consistent with source documents
  • Prior to starting a study and while a study is ongoing, ensure that the study, clinical trial protocol, informed consent form, recruitment materials, and other documents provided to the subject are approved by the IRB and comply with GCP (Good Clinical Practices) and other regulatory requirements as required.
  • Ensure that the IRB is provided with a copy of the Investigator’s brochure, product monograph, or information about the product or intervention to be studied so the IRB can fully assess the risks involved
  • During the study, ensure the IRB is informed of any changes to the protocol, Investigator’s brochure (or other safety information about the product/intervention), protocol deviations, or unanticipated problems
  • Be thoroughly familiar with the appropriate use of the investigational product (study drug) as described in the protocol and Investigator’s brochure/product monograph and other documents provided by the sponsor
  • Be aware and comply with ICH GCP (International Conference on Harmonization – Good Clinical Practice) and all applicable regulatory requirements
  • Maintain trial documents as specified by guidelines and applicable regulatory requirements
  • Ensure retention of essential documents until at least two years after the last approval of a marketing application or at least two years since formal discontinuation of the investigational product
  • Participate in monitoring visits and sponsor meetings; allow monitoring and auditing by sponsors and inspection by appropriate regulatory agencies
  • Provide access to research-related records to monitors, auditors, representatives of the IRB, and regulatory authorities
  • Ensure participants are informed and receive appropriate therapy and follow-up if the trial is prematurely terminated or suspended for any reason
  • Inform and provide a detailed written explanation of the termination/suspension of the trial to the IRB and, if the investigator terminates the trial without prior agreement, to the study sponsor


Required Skills/Abilities:

  • Understanding of regulatory requirements, principles of GCP and biomedical research ethics.
  • The ability to communicate effectively in a flexible and collaborative manner
  • Critical thinking, dynamic problem-solving skills, and attention to detail
  • Commercial understanding of business operations
  • Ability to travel for work related purposes (Up to 10% travel, as needed, for project team meetings, client presentations and other professional meetings/conferences as needed.)


Education and Experience:

  • Minimum qualifications include a degree in a medicine recognized by the GMC with an active GMC medical license.
  • Training and certification in Good Clinical Practice (GCP)
  • Board certification or board eligibility in a specialty appropriate to the type of research being conducted at the site.



  • Training and certification in Velocity required trainings and Standard Operating Procedures (SOP’s).
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