Postdoctoral Research Assistant in R-loop biology

We are seeking

to appoint a well-trained, enthusiastic and self-motivated scientist to join the laboratory of Associate Professor Natalia Gromak at the Sir William Dunn School of Pathology, University of Oxford. The main interest of the laboratory is to investigate the mechanisms underlying the function of non-canonical RNA/DNA structures (R-loops) in health and diseases. The post-holder will be responsible for managing their own academic research. You will establish and optimise protocols, design and accurately execute experiments and contribute conceptually to the overall research programme. The post-holder will contribute directly to scientific discussions with the Group Leader and other members of the group and collaborators on the project. You will also supervise and train junior staff in molecular biology/biochemistry. The post holder should hold, or be close to completion of, a PhD/DPhil in biochemistry, molecular/cell biology or genetics and have a good understanding of the principals of gene expression in higher eukaryotes. The research project will involve a wide range of molecular biology and biochemical techniques, including RNA work, protein purification, mammalian cell culture, next generation sequencing genome-wide analyses (ChIP) and mass spectrometry. Previous expertise in either molecular mechanisms of transcription, RNA processing, DNA damage or R-loop biology would be essential for this job. You should also have strong publication record, good organizational and communication skills, and being able to work as part of a team. Candidates with experience in genomic analyses, proteomic approaches, imaging analysis, iPS differentiation and bioinformatics would be especially welcome.