Job Description Laboratory Research Scientist in theImmunoSurveillance Lab Reports to: Adrian Hayday Contact term: Thisis a full-time, fixed term position for up to 12 months on Crickterms and conditions of employment. Summary A position isimmediately available for a fixed-term Laboratory ResearchScientist (LRS) in the ImmunoSurveillance laboratory, headed byProfessor Adrian Hayday. The lab is located at The Francis CrickInstitute in London and focuses on investigating tissue-associatedT cells and their contributions to protection against epithelialperturbations that characterise inflammatory diseases and cancers.The post holder will work under the supervision of Professor Haydayand Dr Vivien Kohlhaas, providing experimental support in astate-of-the-art model system study seeking to dissect how thedysregulation of local intestinal T cells may combine with altereddiet to provoke gut inflammation. The hypothesis that this may bean important axis in inflammatory bowel disease, and potentially incolorectal cancer, is fuelled by epidemiologic data and our owngenetic and imunological studies of human patients. The idealcandidate is likely to be a pro-active, focused and productiveindividual, motivated by the development and study of a modelsystem to better understand complex human disease. They will alsobe motivated by the collegial and collaborative work environment,that uses a team ethic to nurture and promote individualexcellence. Excellent time management, communication, attention todetail and organisation skills are essential. The Research GroupProfessor Hayday’s laboratory discovered specific proteinsexpressed by epithelial cells that regulate the composition andactivity of gamma delta T cells that naturally populate bodysurfaces in model animals and in humans. His team is responsiblefor the 'Lymphoid Stress Surveillance' hypothesis (PMID) that hasmore recently led to the concept of “normality sensing” (PMID).These concepts describe how tissue-associated T cells recognise andrespond rapidly to perturbations of epithelial cells that may occurin response to infection or physical and/or chemical stress.Although under-explored, this biology appears fundamental, beingconserved as far back as jawless (agnathan) vertebrates. Moreover,the group has provided substantial scientific evidence that thisbiology can in humans make significant contributions to tumoursurveillance and to protection against severe forms of inflammatorybowel disease. Wu et al, 2022 PMID: 35637401 Hayday et al., 2024PMID: 39361750 Dart et al., 2023 PMID: 37708268 Details of researchprojects currently being undertaken can be seen at:https://www.crick.ac.uk/research/labs/adrian-hayday Keyresponsibilities These include but are not limited to: /t * /tContribute to specific research projects under the Group Leader’ssupervision /t /t * /t Contribute to tissue-culture experiments inwhich the responses of T cells to different stimuli are studied.Generation of stable stimulator cell lines /t /t * /t Analysis ofcell activation in an in vitro culture system using flow cytometry/t /t * /t Contribute to omics experiments /t /t * /t Contribute todata analysis /t /t * /t Supporting some aspects of in vivoexperiments, including tissue collection, processing and analysis./t /t * /t Keep accurate records of all work carried out. /t /t/t Attend and contribute to group meetings, journal club andinterest group meetings. /t Key experience and competencies Thepost holder should embody and demonstrate our core Crick values:bold, open and collegial, in addition to the following: Essential/t * /t BSc or MSc in Immunology, Metabolism, Biology,Biochemistry, Biomedical Sciences, or Molecular Biology /t /t * /tProficiency in key aspects of cell culture and sterile technique /t/t * /t Fluent with PCR and other basic molecular techniques /t /t/t Experience in flow cytometry /t /t * /t Firm understanding ofexperimental design principles /t /t * /t Strong quantiatationalskills /t /t * /t Growing capacity and desire to workindependently, and also be capable of interacting within a group /t/t * /t Strong organisational and record-keeping skills /t /t * /tAbility to describe and present data /t Desirable /t * /t A PhD /t/t * /t Experience doing experimental research in a field involvingimmunology, metabolism, and/or molecular biology /t /t * /tExperience with epithelial cell biology /t /t * /t Experience withlentivirus/retrovirus production and application to mammalian cells/t /t * /t Experience with animal handling and tissue processing /t/t * /t Holder of UK Animal scientific procedures personal licence/t The post involves undertaking specific research projects, underthe guidance of the Group Leader and his post-doctoral associate,Dr Kohlhaas. Applicants should have demonstrated a growing capacityto carry out independent basic research projects once the goals andapproaches are clearly outlined. About Us At the Crick, we conductresearch at the forefront of biomedical research. We combine rigourwith an open and collaborative culture, and are outward-looking,reflecting our status as a partnership of six organisations aimingto pool knowledge, ideas and resources. We have a wide researchportfolio with no divisions or departments, bringing biomedicalresearchers together with clinicians, physical scientists andapplied scientists from our pharmaceutical partners. We aim toattract the most talented researchers and support them to tackleinnovative research questions. Our science technology platformsprovide our researchers with access to state-of-the-art technologyand expertise. We provide an excellent learning environment withdedicated education programmes in public engagement with science,education and personal development, and a postdoc trainingprogramme that prepares scientists for leadership roles in science./t * /t If you are interested in applying for this role, pleaseapply via our website. /t /t * /t All offers of employment aresubject to successful security screening and continuous eligibilityto work in the United Kingdom. /t /t * /t If you require a visa towork in the UK we will help support your application should you besuccessful /t Find out what benefits the Crick has to offer: Formore information on our great pay and benefits package please clickhere: [...] Equality, Diversity & Inclusion: We welcomeapplications from all backgrounds. We are committed to providingequal employment opportunities, regardless of ethnicity,nationality, gender, sexual orientation, gender identity, religion,pregnancy, age, disability, or civil partnership, marital or familystatus. We particularly welcome applications from people who areMinority Ethnic as they are currently underrepresented in the Crickat this level. Diversity is essential to excellence in scientificendeavour. It increases breadth and perspective, leading to moreinnovation and creativity. We want the Crick to be a place whereeveryone feels valued and where diversity is celebrated and seen aspart of the foundation for our Institute’s success. The Crick iscommitted to creating equality of opportunity and promotingdiversity and inclusivity. We all share in the responsibility toactively promote dignity, respect, inclusivity and equal treatmentand it is our aim to ensure that these principles are reflected andimplemented in all strategies, policies and practices. 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