Job Description
About DJS AbbVie:
At DJS AbbVie we aspire to create new medicines to improve the lives of patients with serious immunological diseases and cancers. We achieve this by using our proprietary HEPTAD platform to deliver therapeutic antibodies against complex and intractable membrane protein targets. As a biotech company within AbbVie, we combine the agility, team spirit and scientific focus of a biotech with the reach and vision of a global pharmaceutical company. We have discovered a number of drug candidates to date, and continue to grow our exciting portfolio.
About the role:
This role will span mechanistic biology, pharmacology, target selection and antibody discovery. The primary focus will be to develop an understanding of the background biology and signal transduction pathways of the proteins targeted by candidate antibodies, and then designand conduct experiments usingin vitrosystems to dissect the pharmacology and mechanism of action of the candidate antibodies. This will inform disease positioning, rational drug combinations, dose selection, clinical biomarker selection, and future target selection. In line with this, the role will connect back to our discovery group, inputting into the identification of targets for new discovery programs.
The successful applicant should have a track record of immunology research in industry or academia. They will be an experimentalist, skilled at interpreting insights from the literature and translating them into actionable experiments. Day-to-day, they will work collaboratively in project teams who are focussed on different programs at different stages of the R&D process. They should therefore be keen to get involved with all aspects of research at DJS. This will necessitate clear communication and excellent time management. Alongside organisational skills, however, they must enjoy adapt to changing priorities in a fast-paced environment.
At DJS, we want to foster innovative scientists performing drug-discover led by cutting-edge science. In this role the successful candidate will develop knowledge across mechanistic biology, pharmacology, and early discovery with visibility across our portfolio of early discovery through to clinical-stage drug candidates. As such this role will bring many career development opportunities. These are extended further by our unique position within AbbVie, which allows access into a much broader, world-leading drug development pipeline and learnings about broader pharmaceutical business.
Successful applicant's key responsibilities
- Bringing energy, enthusiasm and positivity to the company
- Engaging with the literature to build deep understanding of target biology
- Establish and implementin vitroexperimental models for assessing antibody pharmacology and mode of action
- Perform critical laboratory experiments and analysis to develop and extend existing methodologies
- Mentor junior scientists from the benchside in new and novel immunological techniques and methodologies
- Keeping up-to-date with latest developments in immunology by reading literature and attending conferences
- Contribute ideas and suggestions to all DJS programs
- Gather, analyse and present data from a variety of sources to the wider team and organization
- Critical and impartial review of self- and peer-generated laboratory data to create tangible actions
- Maintenance of laboratory experimental records
Qualifications
Applicant’s required attributes
- A PhD in Immunology or a related field or equivalent level of experience
- Have a passion for immunology and translational biology
- Enthusiasm and commitment to drug development research
- Willingness to work with human tissue samples under an HTA
- Proven expertise and experience in:
- Establishingin vitromodels for inflammatory disorders
- Secondaryex vivocell-based assays (such as, for example, FACS/cell sorting, imaging, ELISA/MSD, Western-blot and omics-based approaches such as RNA-seq)
- Statistical analysis, power calculations and experimental design
- Establishing primary cell assays and developing them for reproducible high throughput screening
Applicants desirable characteristics
- Working with preclinical models for therapeutic antibody development
- Have previously held a UK PIL licence (or equivalent) with experience in executingin vivostudies in pre-clinical models
- Building and maintaining collaborative networks across multiple organizations
- Working within an industrial setting on a drug development program
- Working with organoids or organ on a chip models
- Working with contract research organisations
- Antibody binding techniques; ELISA, FACS, SPR etc.
- Evidence of excellent organizational and interpersonal skills including:
- work both independently and as part of a team
- Ability to work efficiently with strong attention to detail
- Ability to build effective working relationships within large organizations and across different time zones
- Ability to work flexible hours when required
- Proven written and oral communicative ability
- Problem-solving skills
- Flexible and adaptable with an all-inclusive goal-orientated mindset
- Working under a Human Tissue Authority license
Additional Information
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
