Key Information

Want to make an application Make sure your CV is up to date, then read the following job specs carefully before applying.Salary:

£37,050 – £45,732 per annum. Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.

Duration of Contract:

Fixed Term for 2 years (in the first instance)

Hours per week:

35 hours per week (Full Time)

Location:

On site, Sutton

Closing Date:

10 November 2024.

Due to the high volumes of applications we receive, we reserve the right to close the advert before the published closing date once we have received a sufficient number of applications. Therefore, we advise that you submit your application as early as possible to avoid disappointment.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Job DetailsWe are seeking to appoint a

Higher Scientific Officer

within the Centre for Protein Degradation to deliver

biology

aspects of the Centre's projects. The postholder will be working in a multidisciplinary team on

discovery

and

validation

of

novel molecular glue

and

PROTAC targets

and

E3 ligases for challenging oncology indications , contributing to our exploratory and

drug discovery

efforts.

Key Requirements

This position is suitable for a strong team player who is technically-minded and passionate about innovative solutions for cancer drug discovery. They should have a

PhD

in

biology

or

biochemistry

with a solid background in

cancer cell biology

and hands-on experience with

in vitro

genetic manipulation techniques

applicable for

target validation

and interrogation of cell signalling pathways. Experience in

targeted protein degradation ,

biochemical , and

pharmacology

assays would be an additional advantage.

Department Information

This position will be based in the ICR's

Centre for Protein Degradation

- a part of the ICR Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signaling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists, and oncology specialists on expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation), identifying drugs using innovative screening platforms and characterising their mechanisms of action. Our research provides a nucleus for other teams internally and externally to explore the therapeutic potential of targeted protein degradation medicines. Together with the ICR academics, ICR CCDD and collaborations with the pharmaceutical industry, we develop these rapidly from the laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients.

We encourage all applicants to look at the attached job pack for more detailed information about this role. For an informal discussion about the role please feel free to contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, via email:

.

About The Institute of Cancer ResearchWhy work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.

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