Harness Therapeutics is seeking to recruit an enthusiastic and talentedBioinformaticianto join our expanding laboratory team at the Babraham Research Campus in Cambridge, one of the UK’s leading biotech hubs.

Harness is developing therapeutics that have the ability to upregulate protein expression within a physiological range for the treatment of neurodegenerative disorders such as Huntington’s Disease.

The individual recruited into this position will play a crucial role in the progression of key pipeline programmes for the treatment of disease with high unmet medical need.

Candidates must be highly collaborative, technically skilled, and motivated to work in a fast-paced, dynamic environment.

Key Areas of Responsibility:

Reporting to our Principal Bioinformatician you will be responsible for conducting bioinformatics analysis and continue to shape the bioinformatics infrastructure as we transition from hybrid to cloud-based systems, such as AWS.

• Collaborate with research scientists to define key questions, design experiments, and provide bioinformatics support
• Analyse a diverse range of biological data, including but not limited to bulk RNA-seq from both short and long-sequence reads, smRNA-seq, scRNA-seq, and WGS/WES data
• Communicate bioinformatics analyses effectively to stakeholders and team members within the company
• Ensure the validity, reliability, and reproducibility of data and analytical methods
• Maintain accurate and comprehensive records of all analysis projects, including managing and version-controlling code and programs used for analysis and tool development
• Contribute to the implementation of current and future bioinformatics infrastructure requirements
• Identify and develop innovative techniques for data analysis and visualization. Build and maintain the associated computational resources, such as software packages, databases, or web-based tools for analysis and visualization.

Preferred Skills and Qualifications:

• A Masters or PhD degree (or equivalent experience) in Bioinformatics, Computational Biology, Data Science, Machine Learning, or similar
• Demonstrated proficiency in programming languages, such as Python or R, with expertise in R/Bioconductor frameworks
• Proven experience in developing and implementing NGS (Next-Generation Sequencing) pipelines using workflow management tools like Nextflow or Snakemake
• Solid experience working in High-Performance Computing (HPC) environments using job scheduling systems like Slurm, alongside advanced knowledge of the Linux operating system, including shell scripting and Bash
• Comprehensive experience in the analysis of NGS datasets, including quality checks, data processing, interpretation, and the creation of high-quality data visualizations.

Desirable Skills and Experience:

• Familiarity with cloud computing platforms such as AWS, Microsoft Azure, or Google Cloud, including experience in their application to bioinformatics
• Understanding of best practices for designing, implementing, and optimizing scalable and reproducible bioinformatics workflows in cloud-based environments

Benefits:

• Competitive remuneration including eligibility for annual bonus
• Eligibility for share options
• Company pension with generous company contributions
• Health insurance plan for employee, partner and dependents
• Death in service insurance
• 28 days holiday + bank holidays
• Hybrid working policy
• Located on the beautiful Babraham Research Campus south of Cambridge with extensive amenities including a gym.

Should you wish to be considered for this position, please send a CV and cover letter to .