Job description
Site Name:UK - Hertfordshire - Stevenage
Posted Date:Oct 31 2024
Large Molecule Discovery (LMD) is a department dedicated to the discovery of novel and effective biopharma medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation, to molecular engineering and biological and physiochemical profiling.
Within LMD, the Molecular Design and Engineering (MDE) group takes accountability for the engineering and development of single and multi-specific antibodies with enhanced functionalities as well as developability profiling prior to candidate selection, to transform leads into enhanced potential therapeutics.The Advanced Antibody Formats (AAF) team sits within MDE and is involved in a wide variety of activities during the design and prosecution of non-standard mAb (multi-specifics, mAb-protein fusions etc) programmes; the team works with stakeholders to identify and evaluate novel antibody formats, performing relevant antibody engineering, molecule production and characterisation studies, develops processes so the department can accommodate advanced format molecules, and works with and advises teams on bespoke project plans.
An opportunity is now available for a lab-focused enthusiastic Associate Scientist to join AAF to support the progression of multi-specific antibody therapeutic projects and to perform technology and process development work packages. We are looking for a highly motivated and self-starting scientist who is keen to continue developing their skills in both molecular biology and protein production (from expression through to purification and protein characterisation). The successful applicant will be comfortable working as part of a team and particularly enjoy working collaboratively.
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
Discover more about our company wide benefits and life at GSK on our webpageLife at GSK | GSK
In this role you will
- Produce multi-specific antibody-encoding expression constructs, including data registration in GSK databases.
- Work with our in-house antibody expression teams to coordinate/perform protein expression in mammalian cell culture systems and subsequent semi-automated purification.
- Perform biophysical characterisation of multi-specific antibody samples.
- Data analysis and interpretation. Deliver regular oral presentations to share data with project teams.
- Contribute to experimental design, planning and execution of technology development work packages.
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
- Bachelor’s degree, master’s degree or equivalent experience in a life or chemical sciences subject (e.g. Biochemistry, Molecular Biology, Immunology or similar).
- Strong understanding of the fundamentals of molecular biology and protein engineering, with application to antibodies or antibody-related molecular formats.
- Demonstrated ability to work collaboratively as part of a team.
- Self-motivated, flexible approach with good organisational skills.
- Ability to review, assimilate and communicate new information effectively.
- Experience analysing and presenting scientific data packages.
Preferred Qualifications & Skills:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
- Experience with protein expression and purification (in particular antibodies).
- Experience using software for DNA construct design and sequence analyses/validation.
- Experience with the analytical/biophysical characterisation of proteins.
- Knowledge of technologies that underpin bispecific antibodies, novel antibody formats, bioconjugation and/or altered antibody effector function.
- Understanding of industrial antibody discovery processes.
Closing Date for Applications – 13 Nov 2024 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.
Find out more:
Our approach to R&D.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
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