Biotechnology Jobs

Associate Principal Scientist, AI and Computational Tools, Oncology R&D (1-year

This role involves designing and deploying AI-powered tools and computational workflows to accelerate oncology drug discovery, with a focus on immuno-oncology. The scientist will build scalable data infrastructure, develop agentic AI and LLM-integrated solutions, and act as a technical leader across dry-lab and wet-lab teams. The position emphasizes translating complex biological data—such as single-cell and spatial transcriptomics—into reproducible, insight-generating systems while mentoring others in AI adoption and best practices.

AstraZeneca Cambridge, United Kingdom

On-site Contract

Principle Scientist - Cheminformatics

This role involves developing and deploying advanced computational and machine learning models to accelerate drug discovery within GSK's BRADSHAW platform. The Principal Scientist will integrate cheminformatics, quantum mechanics, and AI-driven workflows to support decision-making across discovery programmes. Emphasis is placed on collaboration with multidisciplinary teams and translating complex data into actionable insights for non-experts.

GSK Stevenage, United Kingdom

Principal Scientist, Bioanalytical & Molecular Assays

Lead the development and validation of molecular assays including RT-qPCR, dPCR, and NGS for clinical biomarker programs across Moderna's therapeutic pipeline. Drive end-to-end assay lifecycle management, ensure regulatory compliance with GCLP standards, and collaborate with cross-functional teams to deliver high-quality genomic data. Mentor scientists and integrate advanced analytics and AI-enabled tools to accelerate discovery and translational research.

Moderna Oxford, United Kingdom

Hybrid Permanent

Principal Scientist, Bioanalytical & Molecular Assays

This role involves leading the development and validation of advanced molecular assays—including RT-qPCR, dPCR, and NGS-based methods—for clinical biomarker programs at Moderna. The scientist will drive end-to-end assay lifecycle management, ensure compliance with GCLP and regulatory standards, and collaborate across multidisciplinary teams to generate high-quality genomic data. A key focus is integrating genomics, bioinformatics, and clinical insights to support drug development and inform future pipeline strategies.

Moderna

Hybrid Permanent

ML Research Engineer, London

Develop and optimise cutting-edge AI models at the intersection of machine learning and drug discovery, translating research into scalable, production-ready systems. Work on foundational models like Diffusion networks, Transformers, and GNNs, building robust infrastructure and data pipelines while collaborating closely with scientists. Focus on advancing a digital biology platform to accelerate rational drug design across multiple therapeutic areas.

Isomorphic Labs London, United Kingdom

On-site Permanent

Head of Computer-Aided Drug Discovery (CADD)

Lead a computational drug discovery team focused on structure- and fragment-based design, integrating AI/ML, cheminformatics, and advanced simulation methods into multidisciplinary drug discovery programmes. Drive computational strategy while maintaining hands-on involvement in projects from hit identification through to candidate nomination. Collaborate closely with medicinal chemistry, structural biology, and biophysics teams to deliver innovative therapeutics.

VRS UK Cambridge, Cambridgeshire, United Kingdom

Senior Principal Data Scientist

This role involves leading advanced data science initiatives in drug development, using machine learning, AI, and statistical modeling on clinical and real-world data. The scientist will translate complex business questions into analytical solutions, develop innovative algorithms, and collaborate with internal and external stakeholders to inform decision-making. Work includes hands-on analysis, pipeline development, and methodological innovation using R, Python, and data integration tools.

Novartis London, United Kingdom £57,050 – £105,950 pa

Senior Scientist - ELN & Data Specialist, Global Technical Development

This role involves hands-on administration, configuration, and continuous improvement of an Electronic Lab Notebook (ELN) platform to support R&D and Technical Development laboratories. The scientist will define ELN standards, design workflows and templates, integrate systems, and develop data repositories to enable data-driven decision-making. Collaboration with cross-functional teams is essential to ensure compliance, data integrity, and effective use of the ELN across scientific operations.

Orchard Therapeutics London, United Kingdom

Hybrid Permanent

Principal Scientist (Comp. Bio/ML) - Director Level

This role involves leading the scientific evaluation and application of foundation models in drug development and translational research. The individual will act as a key collaborator to research, product, and business teams, translating advanced biology and machine learning into practical customer solutions. Mentoring junior scientists and contributing to real-world discovery workflows are central to the position.

Helical London, United Kingdom

Hybrid Permanent

Principal Scientist - Sensors & Diagnostics

This role involves leading the development of electrochemical biosensors and diagnostic assays, with deep involvement in experimental design, sensor optimisation, and translational R&D. The scientist will solve challenges in signal stability, manufacturability, and assay integration, working across electrochemistry, biofunctionalisation, and product commercialisation. It's a hands-on leadership role focused on turning scientific innovation into viable diagnostic products.

Vector Recruitment Larbert, Stirling And Falkirk, United Kingdom

Associate Principal Scientist – Tides Downstream Processing Expert

Lead downstream process development for synthetic peptides and oligonucleotides, focusing on scalable purification, cleavage, and isolation technologies. Design and execute lab and in silico studies to optimise processes, resolve technical challenges, and implement innovative technologies. Work across multidisciplinary teams and external partners to scale up and transfer processes for manufacturing.

AstraZeneca Macclesfield, United Kingdom

Regulatory Affairs Specialist - Medical Devices

This role involves leading quality assurance and regulatory affairs initiatives within a global medical devices company, working across European, American, and Asian regulatory standards. You will develop and implement solutions for compliance and management systems in a highly technical R&D and manufacturing environment. The position offers exposure to emerging regulated industries and complex, international projects.

Newton Colmore Cambridge, Cambridgeshire, United Kingdom £42,000 – £46,000 pa

On-site Permanent

Research Associate in MSK Immunology & Data Science

This role involves conducting translational research in immune-mediated musculoskeletal diseases, with a focus on inflammatory arthritis. The researcher will apply advanced bioinformatics techniques to human tissue-derived omics data, working within a multidisciplinary team and collaborating through the ARCADIA network. The position emphasizes computational analysis using R and Python to identify novel disease pathways in underserved patient groups.

Newcastle University Newcastle upon Tyne, Northern England, United Kingdom £36 – £46 pa

Contract

Principal Investigators (All Levels) - Generative Biology Institute

Leads an independent research group focused on advancing the engineering of biology, with a focus on genome synthesis and functional DNA design. Works collaboratively within a multidisciplinary institute to pioneer transformative applications in health, agriculture, and clean energy. Involves mentoring early-career researchers, shaping cutting-edge facilities, and driving long-term, scalable biological solutions.

Ellison Institute of Technology Oxford, United Kingdom

On-site Permanent

Postdoctoral Research Fellow (Liu Lab) - Generative Biology Institute

This role involves conducting advanced research in synthetic evolution, focusing on macromolecular sequence-function relationships and accelerated gene evolution using in vivo systems like OrthoRep. The postdoc will generate large-scale datasets for antibodies and enzymes, explore de novo gene function emergence, and integrate experimental work with machine learning design models. The position emphasizes innovation, collaboration, and translating findings into scalable biological solutions.

Ellison Institute of Technology Oxford, United Kingdom £40,000 pa

On-site Permanent