Develops and executes global and regional regulatory strategies for oncology assets, ensuring optimal labelling and approvals while maintaining compliance. Works with the Global Regulatory Lead and cross-functional teams to shape development plans and support submissions and interactions with regulatory authorities across multiple regions.
Develops and executes global and regional regulatory strategies for oncology assets, ensuring optimal labelling and approvals while maintaining compliance. Works closely with the Global Regulatory Lead and cross-functional teams to align regulatory plans with development strategy and support authority interactions and submissions across multiple regions.
Acts as case management subject matter expert for assigned clinical trials, overseeing safety reporting plans, vendor performance and ICSR compliance. Leads pharmacovigilance processes, supports GxP inspections and audits, and provides study-specific training to vendors and internal teams. Requires deep PV and regulatory knowledge in a multinational pharmaceutical setting.
Join the model performance and scaling team to implement and optimize LLM post-training methods on frontier models, working with JAX or PyTorch, parallelism strategies and GPU architectures. You will diagnose bottlenecks in distributed training and inference, deploy low-precision methods, and collaborate with research teams to turn new methods into production systems for drug design.
Lead computational drug design programs from hit identification through candidate selection, applying AI/ML to cheminformatics workflows and shaping the internal drug design engine. Roles span Program Lead or Computational Chemistry Lead, with some positions managing 2-3 computational chemists in a hybrid Cambridge, MA team.
Leads strategic sourcing and evaluation of late-stage external clinical assets in Immunology, from Phase 2 through marketed drugs. Sits on the Therapy Area Leadership Team, co-leads New Product Opportunity reviews, engages external KOLs and investigators, and drives cross-functional due diligence with BD to close deals.
Leads CMC regulatory strategy for international submissions, reviewing documentation for submission-readiness and guiding manufacturing and quality teams. Over time, directs interactions with health authorities, maintains submission templates, and oversees multiple programs including CMC change controls. Based in Basel within a 70/30 in-office model.
Lead CMC regulatory strategy for global submissions including IND, CTA, BLA and MAA, and oversee agency correspondence and compliance for mRNA product development. Review documentation for submission-readiness, drive health authority interactions, and advise manufacturing, quality and development teams on regulatory change controls across vaccines, oncology and rare disease programmes.
Perform complex clinical procedures such as spirometry, bronchodilator and challenge testing, oscillometry, FeNO, lung volume and DLCO testing, plus nasal and airway sampling and exercise testing. Collect and report clinical data, manage study-specific physiological equipment, and support Phase I-IV trials across respiratory and other therapeutic areas. Full training provided, ideal for recent graduates.
Perform complex clinical procedures such as ECG, phlebotomy, spirometry, cannulation and cardiac telemetry on trial volunteers, and collect and report data per protocol. Support Phase I-IV studies at a hospital-based research facility, ensuring compliance with GCP and SOPs while orienting volunteers and assisting nursing colleagues.
Leads signal detection and validation for complex pharmaceutical products, using computer-assisted tools to mine internal safety data, FDA AEMS, WHO VigiBase and EMA EudraVigilance. Independently develops product-specific surveillance plans, presents findings to Safety Management Teams, and mentors scientists while exploring novel methodologies. Based in High Wycombe with up to 10% international travel.
Hands-on individual contributor building and deploying agentic AI and predictive foundation models for in silico biology, including perturbation prediction and virtual cell models, to accelerate drug target identification and validation. Partners with therapeutic area scientists across Oncology and BioPharmaceuticals, writing production-quality Python pipelines and contributing to publications.
A cross-institutional PhD studentship analysing whole genome sequencing data from millions of individuals across UK Biobank, All of Us and Our Future Health to identify rare causal variants for musculoskeletal disorders, then functionally validating them in human cell and tissue models using CRISPR-Cas9, transcriptomics and cellular phenotyping. Split between computational genomics at Exeter and laboratory work at Oxford, it develops a dual skill set in statistical genetics and experimental validation.
Serves as primary medical accountability for Phase 1–3 clinical trials in neuroscience, leading medical monitoring, safety assessment and benefit/risk analysis within a matrixed study delivery team. Partners with clinical scientists on protocol design, site interactions and health authority submissions, and builds relationships with principal investigators and thought leaders.
Supports late-stage oncology clinical development in collaboration with a Clinical Scientist Program Lead, covering study start-up, execution, close-out, data analysis and regulatory filings. Involves drafting protocols and CRFs, reviewing data and contributing to submissions, with a focus on CAR T-cell and multiple myeloma programmes.
