27 jobs for “Protein Engineer”
Alloy Therapeutics UK Ltd Cambridge £45,000 – £50,000 pa
Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.
CureAge Therapeutics London
Lead the computationally guided design of a lipid nanoparticle delivery platform, applying chemical and biophysical principles to optimise LNP composition and formulation. Use AI-enabled chemistry, cheminformatics, predictive models and molecular modelling to prioritise formulation components, working closely with the experimental team and founding team in a small start-up.
Ellison Institute of Technology Oxford
Develops and optimises high-throughput enzyme assays to characterise plant protein variants from AI-assisted design and evolutionary discovery. Works with computational scientists, automation engineers and roboticists to build scalable protein expression, purification and biochemical characterisation pipelines, informing protein engineering and crop yield decisions.
ISR Recruitment Oxford £520 – £532 pd
Lead a laboratory-based immunology team, designing in vitro pharmacology assays and coordinating in vivo efficacy studies with CROs to advance biologic therapies for autoimmune diseases. Involves target identification, ex vivo profiling, and cross-functional work with protein engineering, biomarkers and translational medicine, plus IND documentation and publications.
Evotec Abingdon
Owns Evotec's in silico therapeutics design capability, uniting computational chemistry, generative and modality design (small molecules, peptides, protein engineering, degraders, molecular glues) and predictive ADMET/safety under one mandate. A newly created unit within the In Silico & AI group with an explicit build mandate: set technical vision, grow a multi-site team, and industrialise repeatable, benchmarked methods across partner programmes.
Gilead Sciences Oxford
Lead a team of scientists developing novel biologic therapies for autoimmune disease, overseeing in vitro and in vivo pharmacology studies for lead and early discovery programs. Collaborate across immunology, protein engineering, translational medicine and biomarkers to deliver data packages for progression to development, while mentoring staff and contributing to INDs and patents.
EMBL-EBI Saffron Walden £3,452 pm
Designs and develops software and APIs for the UniProt protein data services and website, serving a global scientific community. Also handles design, maintenance and monitoring of the website's cloud infrastructure, with a focus on scalability, well-tested code and distributed big-data processing. Works in a dynamic interdisciplinary team of engineers and bioinformaticians alongside biologists.
Ellison Institute of Technology Oxford
Builds and leads a molecular biology and synthetic biology function within a plant science institute, setting technical strategy for high-throughput assays, sequencing-based readouts, CRISPR guide design and multiplex editing. Acts as a responsive core facility, coaching scientists on experimental design and integrating with bioinformatics, tissue culture and phenotyping teams. Combines deep technical direction with people leadership rather than routine bench work.
Recursion Salt Lake City, United States
Develop, optimize and validate cell-based and biochemical assays for automated high-throughput screening, running workflows at scale across 384- and 1536-well formats. Work in a cross-disciplinary team with biologists, automation and data scientists, documenting methods so assays transfer reliably. A 9-month contractor role, Monday to Friday, 9am-5pm.
Basecamp Research London
Owns the peptide and protein platform as a commercial product, spanning market and competitive intelligence, target product profiles, roadmap and packaging decisions, and go-to-market positioning. Sits between model, data and science teams and business development, and is accountable for partner engagement and revenue generation. Requires deep peptide therapeutics and licensing deal expertise.
Lila Sciences London US$268,000 – US$384,000 pa
Conducts original computational biology research for AI safety, investigating how LLMs, specialised biological models, agents and automated laboratories combine to change what is biologically feasible. Spans protein and nucleic-acid design, cellular systems and biological delivery, translating risk judgments into dual-use policy boundaries, evaluation priorities and mitigation requirements alongside threat modellers and red-teamers.
CSL Maidenhead
This role involves leading the R&D Resource and Schedule Management capabilities, defining the mission, governance, and operating model. Responsibilities include capacity and demand management, scenario planning, and stakeholder engagement to ensure alignment with organizational goals and portfolio priorities.
Evotec Abingdon
Leads Evotec's consolidated AI Accelerator, owning machine learning, generative and agentic AI, and therapeutic hypothesis groups. Sets the AI vision and roadmap, makes build/buy/partner decisions for the AI stack, and turns proprietary multi-omics and experimental data into predictive models and reusable IP. Acts as the senior external technical voice for AI in drug discovery.
Nexus Life Sciences Belfast £50,000 – £60,000 pa
Leads a Clinical Method Development and Validation team, overseeing bioanalytical method delivery for a New Product Development programme. Provides technical leadership in a GLP-compliant lab, acting as expert in extraction techniques and optimising HPLC, UPLC and LCMSMS systems while mentoring the team.
CSL Maidenhead US$212,000 – US$251,000 pa
Leads the full statistical contribution to a clinical development programme, defining statistical strategy for trial design, analysis and regulatory submissions, and representing Biostatistics in interactions with the FDA, EMA and PMDA. Also manages outsourcing to CROs/FSPs and contributes to governance and development-plan decisions across therapeutic areas.
Vertex Pharmaceuticals Oxford
Lead the DMPK team at Vertex's Oxford site, shaping strategy and operations while sitting on both the Global DMPK and Oxford Site leadership teams. The role directs ADME science across discovery and development programmes, partners with Medicinal Chemistry, Biology, Preclinical Safety and Clinical Pharmacology, and oversees regulatory documentation such as INDs and marketing applications. It combines deep small-molecule DMPK expertise with hiring, mentoring and resource planning.
Moderna Oxford
Designs and delivers immunogenicity and bioanalytical strategies for regulated clinical programmes, developing ADA, nAb, PK and PD assays using ELISA, MSD and cell culture. Works with multidisciplinary teams to validate assays, manage reagents and SOPs, and integrate digital and AI-enabled tools. Site-based at Harwell within a growing mRNA-focused team.
