15 jobs for “Protein Engineer”
Alloy Therapeutics UK Ltd Cambridge £45,000 – £50,000 pa
Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.
CureAge Therapeutics London
Lead the computationally guided design of a lipid nanoparticle delivery platform, applying chemical and biophysical principles to optimise LNP composition and formulation. Use AI-enabled chemistry, cheminformatics, predictive models and molecular modelling to prioritise formulation components, working closely with the experimental team and founding team in a small start-up.
Ellison Institute of Technology Oxford
Develops and optimises high-throughput enzyme assays to characterise plant protein variants from AI-assisted design and evolutionary discovery. Works with computational scientists, automation engineers and roboticists to build scalable protein expression, purification and biochemical characterisation pipelines, informing protein engineering and crop yield decisions.
ISR Recruitment Oxford £520 – £532 pd
Lead a laboratory-based immunology team, designing in vitro pharmacology assays and coordinating in vivo efficacy studies with CROs to advance biologic therapies for autoimmune diseases. Involves target identification, ex vivo profiling, and cross-functional work with protein engineering, biomarkers and translational medicine, plus IND documentation and publications.
Evotec Abingdon
Owns Evotec's in silico therapeutics design capability, uniting computational chemistry, generative and modality design (small molecules, peptides, protein engineering, degraders, molecular glues) and predictive ADMET/safety under one mandate. A newly created unit within the In Silico & AI group with an explicit build mandate: set technical vision, grow a multi-site team, and industrialise repeatable, benchmarked methods across partner programmes.
EMBL-EBI Saffron Walden £3,452 pm
Designs and develops software and APIs for the UniProt protein data services and website, serving a global scientific community. Also handles design, maintenance and monitoring of the website's cloud infrastructure, with a focus on scalability, well-tested code and distributed big-data processing. Works in a dynamic interdisciplinary team of engineers and bioinformaticians alongside biologists.
Ellison Institute of Technology Oxford
Builds and leads a molecular biology and synthetic biology function within a plant science institute, setting technical strategy for high-throughput assays, sequencing-based readouts, CRISPR guide design and multiplex editing. Acts as a responsive core facility, coaching scientists on experimental design and integrating with bioinformatics, tissue culture and phenotyping teams. Combines deep technical direction with people leadership rather than routine bench work.
Basecamp Research London
Owns the peptide and protein platform as a commercial product, spanning market and competitive intelligence, target product profiles, roadmap and packaging decisions, and go-to-market positioning. Sits between model, data and science teams and business development, and is accountable for partner engagement and revenue generation. Requires deep peptide therapeutics and licensing deal expertise.
CSL Maidenhead US$212,000 – US$251,000 pa
Leads the full statistical contribution to a clinical development programme, defining statistical strategy for trial design, analysis and regulatory submissions, and representing Biostatistics in interactions with the FDA, EMA and PMDA. Also manages outsourcing to CROs/FSPs and contributes to governance and development-plan decisions across therapeutic areas.
CSL Breda, Netherlands US$212,000 – US$251,000 pa
Leads the full scope of statistical contribution to a clinical development programme, defining statistical strategy and methodologies for trial design, analysis and regulatory submissions. Represents Biostatistics in interactions with authorities such as FDA, EMA and PMDA, and manages outsourcing or internal statistical programmers. Two positions support multiple therapeutic areas.
Vertex Pharmaceuticals Oxford
Lead the DMPK team at Vertex's Oxford site, shaping strategy and operations while sitting on both the Global DMPK and Oxford Site leadership teams. The role directs ADME science across discovery and development programmes, partners with Medicinal Chemistry, Biology, Preclinical Safety and Clinical Pharmacology, and oversees regulatory documentation such as INDs and marketing applications. It combines deep small-molecule DMPK expertise with hiring, mentoring and resource planning.
Moderna Oxford
Designs and delivers immunogenicity and bioanalytical strategies for regulated clinical programmes, developing ADA, nAb, PK and PD assays using ELISA, MSD and cell culture. Works with multidisciplinary teams to validate assays, manage reagents and SOPs, and integrate digital and AI-enabled tools. Site-based at Harwell within a growing mRNA-focused team.
CSL Opfikon, Switzerland US$212,000 – US$251,000 pa
Leads the full statistical contribution to a clinical development programme, defining statistical strategy for trial design, analysis and regulatory submissions, and representing Biostatistics in interactions with the FDA, EMA and PMDA. Also manages outsourcing to CROs and internal statistical programmers, and supports departmental improvement initiatives.
CSL Maidenhead
Leads strategic sourcing and evaluation of external innovation opportunities in Haematology, identifying preclinical to Phase 1 assets and shaping early partnering strategies. Sits on the Therapeutic Area Leadership Team, co-leads New Product Opportunity reviews, drives cross-functional due diligence and works with Business Development on deal execution. Hybrid, three days a week at an R&D hub site.
CSL Opfikon, Switzerland
Leads strategic sourcing and evaluation of external innovation opportunities in Haematology, identifying preclinical to Phase 1 assets and shaping early partnering strategies. Sits on the Therapeutic Area Leadership Team, co-leads New Product Opportunity reviews, drives cross-functional due diligence, and works with Business Development on deal execution. Hybrid, three days a week at an R&D hub site.
CSL Opfikon, Switzerland
Leads strategic sourcing and evaluation of late-stage external clinical assets in Immunology, from Phase 2 through marketed drugs. Sits on the Therapy Area Leadership Team, co-leads New Product Opportunity reviews, engages external KOLs and investigators, and drives cross-functional due diligence with BD to close deals.
CSL Maidenhead
Leads strategic sourcing and evaluation of late-stage external clinical assets in Immunology, from Phase 2 through marketed drugs, as the senior S&E leader within the Therapy Area Leadership Team. Drives proactive sourcing, cross-functional due diligence, and KOL engagement, partnering with BD to advance high-priority opportunities through negotiation and deal close.
