35 jobs for “Protein Engineer”
Alloy Therapeutics UK Ltd Cambridge £45,000 – £50,000 pa
Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.
CureAge Therapeutics London
Lead the computationally guided design of a lipid nanoparticle delivery platform, applying chemical and biophysical principles to optimise LNP composition and formulation. Use AI-enabled chemistry, cheminformatics, predictive models and molecular modelling to prioritise formulation components, working closely with the experimental team and founding team in a small start-up.
Evotec Macclesfield
Lead the design, engineering, expression, purification and characterisation of complex biologic therapeutics including monoclonal, bispecific and multispecific antibodies. Acts as biologics scientific lead on client-facing drug discovery programmes, mentoring junior scientists and shaping project strategy within a multidisciplinary Protein Sciences team.
Latent Labs London
Architect novel generative models to design functional proteins, working in an interdisciplinary team of ML researchers, protein engineers and biologists. Split roughly 90/10 between building and evaluating models against wet lab results and self-development, with heavy emphasis on data pipelines, cloud training and production-quality code.
Ellison Institute of Technology Oxford £40,000 pa
Postdoctoral role in the Liu Lab for Synthetic Evolution, designing and troubleshooting experiments, analysing complex data with computational and statistical tools, and publishing high-quality research. The lab invented OrthoRep for continuous accelerated gene evolution, with projects spanning antibody sequence-affinity datasets, enzyme sequence-function maps, and de novo gene function emergence. Involves mentoring junior researchers and collaborating across multidisciplinary teams.
Ellison Institute of Technology Oxford
Lead a flagship research programme in biological nitrogen fixation, engineering novel nitrogen-fixing systems into plants through metabolic and protein engineering. Recruit and manage a team of postdocs and PhD students, drive stage-gated translational research from lab to field, and build collaborations across EIT Oxford and commercial partners.
ISR Recruitment Oxford £520 – £532 pd
Lead a laboratory-based immunology team, designing in vitro pharmacology assays and coordinating in vivo efficacy studies with CROs to advance biologic therapies for autoimmune diseases. Involves target identification, ex vivo profiling, and cross-functional work with protein engineering, biomarkers and translational medicine, plus IND documentation and publications.
Latent Labs London
Work at the interface between frontier generative models and pharmaceutical/biotech customers, deploying, adapting and fine-tuning models in customer environments. Build production-grade API integrations, model-serving infrastructure and ML data pipelines, while acting as technical point of contact for partners. Combines deep ML research with customer-facing delivery in an interdisciplinary team.
Gilead Sciences Oxford
Lead a team of scientists developing novel biologic therapies for autoimmune disease, overseeing in vitro and in vivo pharmacology studies for lead and early discovery programs. Collaborate across immunology, protein engineering, translational medicine and biomarkers to deliver data packages for progression to development, while mentoring staff and contributing to INDs and patents.
University of East Anglia Norwich £21,805 pa
A four-year PhD project using engineering biology to develop bacterial and human ferritin nanocages for encapsulating small molecules, peptides and proteins, with applications in biocatalysis and therapeutics. The work spans protein purification, bioanalytical methods, spectroscopy, mass spectrometry and microscopy, targeting enzymes such as hydrogenase and targeted molecular delivery. Based in the Le Brun lab at UEA's School of Chemistry, Pharmacy and Pharmacology.
Nuclera Cambridge
Full-stack engineer building customer-facing cloud and instrument software plus internal tools supporting in-house protein screening services. Owns features end to end, from gathering requirements with biologists and stakeholders through technical design, implementation and testing across backend, frontend, dev-ops and QA.
UCL London £68,284 – £76,244 pa
Develops and leads an AI-driven research programme in biomolecular design and molecular interactions, spanning protein-ligand, protein-protein and protein-nucleic acid systems. Combines structural biology, biophysics, quantitative biology and machine learning, while teaching computational biology and biomolecular design at undergraduate and postgraduate level, including a new MRes in AI for Bioscience.
University of Exeter Exeter £21,805 pa
An interdisciplinary PhD studentship combining computational genomics at Exeter with stem-cell biology and CRISPR editing at Cambridge. The student will analyse whole-genome sequencing data from large multi-ancestry cohorts, integrate genetic signals with epigenetic maps and AI tools like AlphaGenome, and build iPSC-derived visceral and subcutaneous adipocyte models to functionally test prioritised regulatory variants.
Roche Welwyn
Builds physics-grounded machine learning models that combine quantum chemistry with ML to predict small-molecule energetics, conformation, reactivity, binding affinity and free energy. Works in a small-molecule team within AI for Drug Discovery, creating synthetic quantum-mechanics datasets and deployable pipelines that feed molecular-design tools across Roche, with a strong publication and open-source focus.
Roche Basel, Switzerland
Build physics-grounded machine learning models that combine quantum chemistry with ML to predict small-molecule energetics, conformation, reactivity, binding affinity and free energy. Work in a small-molecule team within AI for Drug Discovery, creating synthetic QM datasets and deployable, scalable pipelines that feed molecular-design tools across Roche, alongside computational and experimental scientists.
University of Sussex Brighton £38,784 – £46,049 pa
Investigates how phosphorylation regulates RNA polymerase II transcription, RNA processing and gene expression, combining biochemistry, structural biology, cell biology and functional genomics. The role involves maintaining mammalian cell culture, generating degron-tagged cell lines, transcriptome analyses and in vitro transcription reconstitution, with scope to develop independent ideas within a collaborative group.
Basecamp Research London
Owns the peptide and protein platform as a commercial product, spanning market and competitive intelligence, target product profiles, roadmap and packaging decisions, and go-to-market positioning. Sits between model, data and science teams and business development, and is accountable for partner engagement and revenue generation. Requires deep peptide therapeutics and licensing deal expertise.
