13 jobs for “Protein Engineer”
Alloy Therapeutics UK Ltd Cambridge £45,000 – £50,000 pa
Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.
CureAge Therapeutics London
Lead the computationally guided design of a lipid nanoparticle delivery platform, applying chemical and biophysical principles to optimise LNP composition and formulation. Use AI-enabled chemistry, cheminformatics, predictive models and molecular modelling to prioritise formulation components, working closely with the experimental team and founding team in a small start-up.
Evotec Macclesfield
Lead the design, engineering, expression, purification and characterisation of complex biologic therapeutics including monoclonal, bispecific and multispecific antibodies. Acts as biologics scientific lead on client-facing drug discovery programmes, mentoring junior scientists and shaping project strategy within a multidisciplinary Protein Sciences team.
Ellison Institute of Technology Oxford £40,000 pa
Postdoctoral role in the Liu Lab for Synthetic Evolution, designing and troubleshooting experiments, analysing complex data with computational and statistical tools, and publishing high-quality research. The lab invented OrthoRep for continuous accelerated gene evolution, with projects spanning antibody sequence-affinity datasets, enzyme sequence-function maps, and de novo gene function emergence. Involves mentoring junior researchers and collaborating across multidisciplinary teams.
Ellison Institute of Technology Oxford
Develops and optimises high-throughput enzyme assays to characterise plant protein variants from AI-assisted design and evolutionary discovery. Works with computational scientists, automation engineers and roboticists to build scalable protein expression, purification and biochemical characterisation pipelines, informing protein engineering and crop yield decisions.
Basecamp Research London
Owns R&D extraction workflow development, adapting and optimising metagenomic DNA/RNA extraction methods across diverse, low-biomass and inhibitor-rich sample types, including HMW extractions for long-read sequencing. Designs controlled experiments, transfers validated methods to production and a global partner network, and works in a data-first lab environment feeding a large gene atlas.
Evotec Macclesfield
Designs and executes work plans for early drug discovery projects within a Protein Sciences team, supporting multiple projects and presenting results to clients. Hands-on role focused on recombinant protein expression using insect cell systems such as BEVS, S2 and Sf9, including construct design, baculovirus generation and troubleshooting difficult targets like membrane proteins.
Nuclera Cambridge
Formulate, dispense and quality-control reagents for a protein discovery platform, operating lab equipment such as pipettes, centrifuges and UPLC systems. The role covers batch documentation, inventory management via ERP and troubleshooting production deviations, working closely with R&D, QA and Supply Chain in a fast-paced lab environment.
Sartorius Glasgow
Performs laboratory techniques under GMP conditions, including cell-based assays, ELISAs and protein characterisation, to test biological products such as monoclonal antibodies, cell and gene therapies and vaccines. Also manages stock and reagents, maintains traceability records, and prepares controlled documentation like SOPs and risk assessments within a nine-person team.
Moderna Oxford
Designs and delivers immunogenicity and bioanalytical strategies for regulated clinical programmes, developing ADA, nAb, PK and PD assays using ELISA, MSD and cell culture. Works with multidisciplinary teams to validate assays, manage reagents and SOPs, and integrate digital and AI-enabled tools. Site-based at Harwell within a growing mRNA-focused team.
Francis Crick Institute London £47,500 pa
Investigates how protein machines remodel microtubules using cryo-electron microscopy, protein reconstitution and fluorescence microscopy. As an early member of a new lab, you will shape the research programme, establish experimental approaches and develop scientific independence while working closely with the group leader.
University of Oxford Oxford £39,424 – £43,984 pa
Carries out laboratory research on synthetic genome DNA assembly, generating constructs and testing new approaches using recombinant DNA methylases. Involves molecular cloning, long DNA molecule extraction, bacterial culture and recombinant protein production and purification, with scope for some bioinformatic analysis. Based in a well-equipped Oxford lab, collaborating on translation of synthetic chloroplast genomes into crop plants such as potato and wheat.
Ellison Institute of Technology Oxford
Lead a flagship research programme in biological nitrogen fixation, engineering novel nitrogen-fixing systems into plants through metabolic and protein engineering. Recruit and manage a team of postdocs and PhD students, drive stage-gated translational research from lab to field, and build collaborations across EIT Oxford and commercial partners.
Ellison Institute of Technology Oxford £40,000 pa
Develops generative protein design models that capture enzyme dynamics and function, designing conformationally dynamic catalysts. Runs computational and statistical analyses, publishes findings, and collaborates with in vivo evolution teams across the institute. Also mentors PhD students and research assistants and pursues translational and IP opportunities.
Ellison Institute of Technology Oxford
Design and conduct experiments on nanopore technologies, single-molecule analysis, and 3D tissue engineering, spanning chemistry, biology, physics and engineering. Postdocs lead development of emerging biotech methods, publish impactful research, and mentor junior researchers within a 100+ researcher institute.
