38 jobs for “Protein Engineer”
Alloy Therapeutics UK Ltd Cambridge £45,000 – £50,000 pa
Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.
CureAge Therapeutics London
Lead the computationally guided design of a lipid nanoparticle delivery platform, applying chemical and biophysical principles to optimise LNP composition and formulation. Use AI-enabled chemistry, cheminformatics, predictive models and molecular modelling to prioritise formulation components, working closely with the experimental team and founding team in a small start-up.
Ellison Institute of Technology Oxford £40,000 pa
Postdoctoral role in the Liu Lab for Synthetic Evolution, designing and troubleshooting experiments, analysing complex data with computational and statistical tools, and publishing high-quality research. The lab invented OrthoRep for continuous accelerated gene evolution, with projects spanning antibody sequence-affinity datasets, enzyme sequence-function maps, and de novo gene function emergence. Involves mentoring junior researchers and collaborating across multidisciplinary teams.
Ellison Institute of Technology Oxford
Develops and optimises high-throughput enzyme assays to characterise plant protein variants from AI-assisted design and evolutionary discovery. Works with computational scientists, automation engineers and roboticists to build scalable protein expression, purification and biochemical characterisation pipelines, informing protein engineering and crop yield decisions.
ISR Recruitment Oxford £520 – £532 pd
Lead a laboratory-based immunology team, designing in vitro pharmacology assays and coordinating in vivo efficacy studies with CROs to advance biologic therapies for autoimmune diseases. Involves target identification, ex vivo profiling, and cross-functional work with protein engineering, biomarkers and translational medicine, plus IND documentation and publications.
Evotec Abingdon
Owns Evotec's in silico therapeutics design capability, uniting computational chemistry, generative and modality design (small molecules, peptides, protein engineering, degraders, molecular glues) and predictive ADMET/safety under one mandate. A newly created unit within the In Silico & AI group with an explicit build mandate: set technical vision, grow a multi-site team, and industrialise repeatable, benchmarked methods across partner programmes.
Gilead Sciences Oxford
Lead a team of scientists developing novel biologic therapies for autoimmune disease, overseeing in vitro and in vivo pharmacology studies for lead and early discovery programs. Collaborate across immunology, protein engineering, translational medicine and biomarkers to deliver data packages for progression to development, while mentoring staff and contributing to INDs and patents.
University of East Anglia Norwich £21,805 pa
A four-year PhD project using engineering biology to develop bacterial and human ferritin nanocages for encapsulating small molecules, peptides and proteins, with applications in biocatalysis and therapeutics. The work spans protein purification, bioanalytical methods, spectroscopy, mass spectrometry and microscopy, targeting enzymes such as hydrogenase and targeted molecular delivery. Based in the Le Brun lab at UEA's School of Chemistry, Pharmacy and Pharmacology.
EMBL-EBI Saffron Walden £3,452 pm
Designs and develops software and APIs for the UniProt protein data services and website, serving a global scientific community. Also handles design, maintenance and monitoring of the website's cloud infrastructure, with a focus on scalability, well-tested code and distributed big-data processing. Works in a dynamic interdisciplinary team of engineers and bioinformaticians alongside biologists.
University of Exeter Exeter £21,805 pa
An interdisciplinary PhD studentship combining computational genomics at Exeter with stem-cell biology and CRISPR editing at Cambridge. The student will analyse whole-genome sequencing data from large multi-ancestry cohorts, integrate genetic signals with epigenetic maps and AI tools like AlphaGenome, and build iPSC-derived visceral and subcutaneous adipocyte models to functionally test prioritised regulatory variants.
Recursion Salt Lake City, United States
Develop, optimize and validate cell-based and biochemical assays for automated high-throughput screening, running workflows at scale across 384- and 1536-well formats. Work in a cross-disciplinary team with biologists, automation and data scientists, documenting methods so assays transfer reliably. A 9-month contractor role, Monday to Friday, 9am-5pm.
University of Sussex Brighton £38,784 – £46,049 pa
Investigates how phosphorylation regulates RNA polymerase II transcription, RNA processing and gene expression, combining biochemistry, structural biology, cell biology and functional genomics. The role involves maintaining mammalian cell culture, generating degron-tagged cell lines, transcriptome analyses and in vitro transcription reconstitution, with scope to develop independent ideas within a collaborative group.
Basecamp Research London
Owns the peptide and protein platform as a commercial product, spanning market and competitive intelligence, target product profiles, roadmap and packaging decisions, and go-to-market positioning. Sits between model, data and science teams and business development, and is accountable for partner engagement and revenue generation. Requires deep peptide therapeutics and licensing deal expertise.
Lila Sciences London US$268,000 – US$384,000 pa
Conducts original computational biology research for AI safety, investigating how LLMs, specialised biological models, agents and automated laboratories combine to change what is biologically feasible. Spans protein and nucleic-acid design, cellular systems and biological delivery, translating risk judgments into dual-use policy boundaries, evaluation priorities and mitigation requirements alongside threat modellers and red-teamers.
CSL Maidenhead
This role involves leading the R&D Resource and Schedule Management capabilities, defining the mission, governance, and operating model. Responsibilities include capacity and demand management, scenario planning, and stakeholder engagement to ensure alignment with organizational goals and portfolio priorities.
Evotec Abingdon
Leads Evotec's consolidated AI Accelerator, owning machine learning, generative and agentic AI, and therapeutic hypothesis groups. Sets the AI vision and roadmap, makes build/buy/partner decisions for the AI stack, and turns proprietary multi-omics and experimental data into predictive models and reusable IP. Acts as the senior external technical voice for AI in drug discovery.
Imperial College London London £48,246 – £58,318 pa
Supports the production and characterisation of recombinant proteins for molecular glue discovery, focusing on expression, purification and characterisation using mammalian cell systems. Contributes to biochemical or biophysical assay development and helps run the laboratory day to day, including equipment upkeep, consumables and waste disposal, within a multidisciplinary chemical biology and proteomics team.
