7 jobs for “Protein Engineer”
Alloy Therapeutics UK Ltd Cambridge £45,000 – £50,000 pa
Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.
CureAge Therapeutics London
Lead the computationally guided design of a lipid nanoparticle delivery platform, applying chemical and biophysical principles to optimise LNP composition and formulation. Use AI-enabled chemistry, cheminformatics, predictive models and molecular modelling to prioritise formulation components, working closely with the experimental team and founding team in a small start-up.
ISR Recruitment Oxford £520 – £532 pd
Lead a laboratory-based immunology team, designing in vitro pharmacology assays and coordinating in vivo efficacy studies with CROs to advance biologic therapies for autoimmune diseases. Involves target identification, ex vivo profiling, and cross-functional work with protein engineering, biomarkers and translational medicine, plus IND documentation and publications.
University of East Anglia Norwich £21,805 pa
A four-year PhD project using engineering biology to develop bacterial and human ferritin nanocages for encapsulating small molecules, peptides and proteins, with applications in biocatalysis and therapeutics. The work spans protein purification, bioanalytical methods, spectroscopy, mass spectrometry and microscopy, targeting enzymes such as hydrogenase and targeted molecular delivery. Based in the Le Brun lab at UEA's School of Chemistry, Pharmacy and Pharmacology.
University of Exeter Exeter £21,805 pa
An interdisciplinary PhD studentship combining computational genomics at Exeter with stem-cell biology and CRISPR editing at Cambridge. The student will analyse whole-genome sequencing data from large multi-ancestry cohorts, integrate genetic signals with epigenetic maps and AI tools like AlphaGenome, and build iPSC-derived visceral and subcutaneous adipocyte models to functionally test prioritised regulatory variants.
University of Sussex Brighton £38,784 – £46,049 pa
Investigates how phosphorylation regulates RNA polymerase II transcription, RNA processing and gene expression, combining biochemistry, structural biology, cell biology and functional genomics. The role involves maintaining mammalian cell culture, generating degron-tagged cell lines, transcriptome analyses and in vitro transcription reconstitution, with scope to develop independent ideas within a collaborative group.
Imperial College London London £48,246 – £58,318 pa
Supports the production and characterisation of recombinant proteins for molecular glue discovery, focusing on expression, purification and characterisation using mammalian cell systems. Contributes to biochemical or biophysical assay development and helps run the laboratory day to day, including equipment upkeep, consumables and waste disposal, within a multidisciplinary chemical biology and proteomics team.
Francis Crick Institute London £47,500 pa
Investigates how protein machines remodel microtubules using cryo-electron microscopy, protein reconstitution and fluorescence microscopy. As an early member of a new lab, you will shape the research programme, establish experimental approaches and develop scientific independence while working closely with the group leader.
University of Oxford Oxford £39,424 – £43,984 pa
Carries out laboratory research on synthetic genome DNA assembly, generating constructs and testing new approaches using recombinant DNA methylases. Involves molecular cloning, long DNA molecule extraction, bacterial culture and recombinant protein production and purification, with scope for some bioinformatic analysis. Based in a well-equipped Oxford lab, collaborating on translation of synthetic chloroplast genomes into crop plants such as potato and wheat.
